注射用白眉蛇毒血凝酶治疗早产儿消化道出血的临床疗效观察

目的：观察注射用白眉蛇毒血凝酶对早产儿消化道出血的疗效。方法：将符合早产儿消化道出血诊断标准的82例患儿随机分为观察组和对照组各41例。两组患儿均给予维生素K1、酚磺乙胺、西咪替丁静脉滴入，1次/天，连用3~5 d，若出血量大者可予输新鲜冰冻血浆；观察组在此基础上给予注射用白眉蛇毒血凝酶0.5 KU胃管注入，同时0.5 KU静脉推注，根据出血情况，1~6 h可重复一次，共2~4次，直至出血停止。结果：观察组总有效率92.7%，对照组总有效率56.0%，两组比较差异有统计学意义（P<0.05）。结论：注射用白眉蛇毒血凝酶治疗早产儿消化道出血疗效显著，未见明显不良反应，可作为早产儿消化道出血常规用药。

To Observe the Clinical Curative Effect on Mangabeys Hemocoagulase Injection Treatment of Premature Infants with Gastrointestinal Bleeding

Objective: To observe the curative effect of injection injection mangabeys hemocoagulase on digestive tract hemorrhage in premature infants. Methods: 82 cases were randomly divided into observation group 41 cases and control group 41 cases. Two groups of children were given vitamin K1, etamsylate, cimetidine intravenous drip, 1 time/day, amuse 3~5 d, if the bleeding head but to lose fresh frozen plasma. On the basis of the observation group was given injection mangabeys hemocoagulase injection of 0.5 KU stomach tube injection, at the same time 0.5 KU intravenous injection, according to bleeding, can be repeated for 1~6 hours, 2~4 time, until the bleeding stops. Results: The observation group total effectiveness 92.7%, the comparison group total effectiveness 56%, there was significant difference between two groups (P<0.05). Conclusion: With the mangabeys hemocoagulase therapy in premature infants with gastrointestinal hemorrhage significantly injection, and no obvious side effect, can be used as a routine use in premature infants gastrointestinal bleeding