2008-2014年武汉地区32家医院大环内酯类抗菌药物应用分析

目的：通过调查分析2008-2014年武汉地区32家医院大环内酯类抗菌药物使用现状，为其合理使用提出建议。方法：通过对阿奇霉素、克拉霉素、地红霉素、罗红霉素、红霉素、环酯红霉素、依托红霉素、交沙霉素、麦迪霉素、乙酰螺旋霉素、吉他霉素、琥乙红霉素、乙酰麦迪霉素、乙酰吉他霉素等大环内酯类抗菌药物的用药量、用药金额、限定日计量（DDD）、用药频度（DDDs）、日均费用（DDC）、排序比等指标进行分析，了解其临床使用现状并预测未来使用趋势。结果：用药量排名前5的药物用药量之和超过整体用量的80%，分别为阿奇霉素、克拉霉素、地红霉素、罗红霉素及红霉素。14个品种中，除克拉霉素和麦迪霉素用药量逐年增长以外，其余12个品种使用量均有不同程度下降。结论：尽管抗菌药物使用监管政策在短时间内起到限制大环内酯类抗菌药物用量的作用，但仍需继续加强监管，以防出现滥用现象。

Analysis of the Drug Application of Macrolide Antibiotics in 32 Hospitals in Wuhan Area from 2008 to 2014

Objective: To give advice on the rational application of the macrolide antibiotics by investigating and analyzing the current situation of their use in 32 hospitals in Wuhan area from 2008 to 2014. Methods: To understand the current situation of their application and predict the tendency of their future situation by analyzing the total consumption amount, total consumption sum, DDD, DDDs, DDC and sequenced ratio of the macrolide antibiotics, such as azithromycin, clarithromycin, dirithromycin, roxithromycin, erythromycin, erythromycin cydocarbonate, erythromycin estolate, josamycin, midecamycin, acetylspiramycin, kitasamycin, erythromycin ethylsuccinate, acetyl midecamycin, acetylkitasamycin, etc. Results: The top five drugs in the list of the consumption amount, accounting for more than 80 percent of the total consumption amount of the 14 macrolide antibiotics are azithromycin, clarithromycin, dirithromycin, roxithromycin and erythromycin. Only the consumption amount of clarithromycin and medemycin increased annually. The consumption amount of other 12 macrolide antibiotics decreased to various degrees. Conclusion: Although the supervision policies of antibiotics had limited the amount of the macrolide antibiotics within a short time, supervision should still be strengthened to prevent abuse of the macrolide antibiotics.