| 五味消毒饮加减方防治非小细胞肺癌患者放疗后放射性肺炎的临床研究 |
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| 引用本文： | 陈思勤,丑天舒,王雅静,何凤姣,俞天俊,向婷婷,周坚.五味消毒饮加减方防治非小细胞肺癌患者放疗后放射性肺炎的临床研究[J].上海中医药杂志,2017,51(11):37-40. |
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| 作者姓名： | 陈思勤 丑天舒 王雅静 何凤姣 俞天俊 向婷婷 周坚 |
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| 作者单位： | 湖南省中医药研究院附属医院肿瘤科,湖南长沙,410006,湖南中医药大学中西医结合学院,湖南长沙,410208,湖南中医药大学中西医结合学院,湖南长沙,410208,湖南省中医药研究院附属医院肿瘤科,湖南长沙,410006,湖南省中医药研究院附属医院肿瘤科,湖南长沙,410006,湖南省中医药研究院附属医院肿瘤科,湖南长沙,410006,湖南省中医药研究院附属医院肿瘤科,湖南长沙,410006 |
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| 基金项目： | 湖南省教育厅科学研究一般项目(16C1214) |
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| 摘 要： | 目的观察五味消毒饮加减方防治非小细胞肺癌患者放疗后放射性肺炎的临床疗效。方法将120例非小细胞肺癌患者随机分为治疗组和对照组,每组60例。对照组予常规放疗、化疗,治疗组在放疗、化疗基础上加用五味消毒饮加减方。放疗及中药疗程均为1个月,观察两组放射性肺炎发生率及病情分级,比较身体机能状态评分(KPS)、肺损伤相关因子血清转化生长因子-β1(TGF-β1)的变化情况。结果 (1)两组完成试验病例共110例,其中治疗组55例、脱落5例,对照组55例、脱落5例,总脱落率为8.3%。(2)疗程结束后,治疗组、对照组的RP发生率分别为5.45%和20.00%,治疗组明显低于对照组(P0.05);两组病情分级比较,差异有统计学意义(P0.05)。(3)组间治疗后比较,KPS评分差异有统计学意义,治疗组评分明显高于对照组(P0.05)。(4)组间治疗后比较,TGF-β1水平差异有统计学意义,治疗组明显低于对照组(P0.05)。结论五味消毒饮加减方防治非小细胞肺癌患者放疗后放射性肺炎(RP),可明显减少RP的发生率,减轻急性放射性肺损害的程度(TGF-β1),改善患者的身体机能状态。
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| 关 键 词： | 五味消毒饮 非小细胞肺癌 放射性肺炎 治未病 清热解毒 益气养阴 |
| 收稿时间： | 2017/6/18 0:00:00 |
Clinical study of Modified Wuwei Xiaodu Decoction in the prevention and treatment of radiation pneumonia in patients with non-small cell lung cancer after chemotherapy |
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| CHEN Si-qin,CHOU Tian-shu,WANG Ya-jing,HE Feng-jiao,YU Tian-jun,XIANG Ting-ting and ZHOU Jian.Clinical study of Modified Wuwei Xiaodu Decoction in the prevention and treatment of radiation pneumonia in patients with non-small cell lung cancer after chemotherapy[J].Shanghai Journal of Traditional Chinese Medicine,2017,51(11):37-40. |
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| Authors: | CHEN Si-qin CHOU Tian-shu WANG Ya-jing HE Feng-jiao YU Tian-jun XIANG Ting-ting and ZHOU Jian |
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| Institution: | Department of Oncology,Hospital Affiliated to Hunan Academy of Chinese Medicine,Changsha,410006,School of Integrated Chinese and Western Medicine,Hunan University of Chinese Medicine,Changsha,410208,School of Integrated Chinese and Western Medicine,Hunan University of Chinese Medicine,Changsha,410208,Department of Oncology,Hospital Affiliated to Hunan Academy of Chinese Medicine,Changsha,410006,Department of Oncology,Hospital Affiliated to Hunan Academy of Chinese Medicine,Changsha,410006,Department of Oncology,Hospital Affiliated to Hunan Academy of Chinese Medicine,Changsha,410006 and Department of Oncology,Hospital Affiliated to Hunan Academy of Chinese Medicine,Changsha,410006 |
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