围手术期质子泵抑制剂预防应激性溃疡合理性评价与分析

目的：调查酒泉市人民医院外科围手术期使用质子泵抑制剂（PPIs）预防应激性溃疡（SU）的情况，促进合理用药。方法：随机抽查酒泉市人民医院2015年6-12月外科手术出院病历700份，对围手术期使用PPIs预防SU的患者进行合理性评价与分析。结果：使用PPIs预防SU的339例患者中，26.25%有预防用药指征。有预防用药指征的患者中，用药品种以奥美拉唑为主，占69.66%；给药途径及用法用量合理率分别为30.34%、75.96%；给药时机及用药疗程合理率分别为51.69%、39.33%。结论：酒泉市人民医院对质子泵抑制剂（PPIs）预防围手术期患者应激性溃疡（SU）存在一些误区，需要加强管理，防止其过度使用。

Evaluation and Analysis on the Rationality of Proton Pump Inhibitors Use for Prevention of Stress Ulcer in the Perioperative Period

Objective: To investigate the situation of proton pump inhibitors use for prevention of stress ulcer in perioperative patients, so as to enhance the level of rational drug use. Methods: The data of 700 surgical patients discharged from our hospital from June 2015 to December 2015 were randomly collected for statistical analysis regarding the rationality of proton pump inhibitors use for stress ulcer prevention in perioperative patients. Results: Of the total 339 cases with PPIs use, only 26.25% were with indications for stress ulcer, among which 69.66% of the PPIs used were omeprazole; the rationality rate of the administration and dosage was 30.34% and 75.96% respectively; 51.69% of the surgical patients used PPIs at the right time, and 39.33% were with the right course of treatment. Conclusion: The application of PPIs for stress ulcer prevention in perioperative patients in our hospital is far from perfection; and great importance should be attached to rational use of PPIs.