| 细辛与维拉帕米镇痛协同作用的实验研究 |
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| 引用本文： | 孙莲芬,王洪涛,陈刚. 细辛与维拉帕米镇痛协同作用的实验研究[J]. 时珍国医国药, 2007, 18(8): 1898-1899 |
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| 作者姓名： | 孙莲芬 王洪涛 陈刚 |
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| 作者单位： | 三峡大学第一临床医学院,湖北,宜昌,443003;宜昌市中心人民医院,湖北,宜昌,443003 |
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| 摘 要： | 目的研究细辛与维拉帕米的镇痛协同作用,为临床联合用药提供理论依据。方法采用小鼠醋酸扭体实验及热板法致痛实验观测实验药物镇痛作用,并用神经盒、多媒体MS-302系统观察其对蟾蜍坐骨神经动作电位的影响。结果细辛及A-V复方制剂对醋酸致小鼠腹痛、热板法致小鼠足痛均有明显的镇痛作用并能抑制蟾蜍坐骨神经动作电位的传导。维拉帕米有弱的镇痛作用,无坐骨神经动作电位阻滞作用。A-V复方制剂的镇痛及抑制神经动作电位传导作用均大于其组分细辛和维拉帕米。结论细辛和维拉帕米有镇痛协同作用。
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| 关 键 词： | 细辛 维拉帕米 镇痛作用 |
| 文章编号： | 1008-0805（2007）08-1898-02 |
| 收稿时间： | 2006-12-21 |
| 修稿时间： | 2006-12-212007-03-11 |
Research of Analgesia Synergism of Asarum and Verapami |
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| SUN Lian-fen,WANG Hong-tao,CHEN Gang. Research of Analgesia Synergism of Asarum and Verapami[J]. Lishizhen Medicine and Materia Medica Research, 2007, 18(8): 1898-1899 |
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| Authors: | SUN Lian-fen WANG Hong-tao CHEN Gang |
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| Abstract: | Objective To research synergetic analgesic effect of Asarum and Verapamil,in order to apply theoretical evidence for clinical administration.Methods Adopt acetic acid turning body experiment and hot board method inducing pain experiment to observe their synergetic effect, and the influence of action potential of toad sciatic nerve by nerve chamber,multi-media MS-302 system.Results Asarum and A-V compound have remarkable analgesic effect of the pain of mice induced by acetic acid turning body and the hot-plate test.Both can inhibit action potential transmission of toad sciatic nerve.Verpamil has faint analgesic effect but can not inhibit action potential transmission of toad sciatic nerve.A-V compound has greater effect of analgesia and inhabiting nerve action potential transmission than its components Asarum and Verapamil.Conclusion Asarum and Verapamil have analgesia synergism. |
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| Keywords: | Asarum Verapamil Analgesia effect |
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