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Magnetic resonance imaging and diffusion-weighted imaging of normal-appearing white matter in children and young adults with tuberous sclerosis complex |
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| Authors: | Sahayini Arulrajah Gulhan Ertan Lori Jordan Aylin Tekes Elizabeth Khaykin Izlem Izbudak Thierry A. G. M Huisman |
| Affiliation: | (1) Division of Pediatric Radiology, Department of Radiology and Radiological Science, Johns Hopkins Hospital, 600 North Wolfe Street, Nelson Basement, B-173, Baltimore, MD 21287-0842, USA;(2) Division of Pediatric Neurology, Johns Hopkins School of Public Health, Baltimore, MD, USA;(3) Department of Mental Health, Johns Hopkins School of Public Health, Baltimore, MD, USA;(4) Division of Neuroradiology, Department of Radiology and Radiological Science, Johns Hopkins Hospital, Baltimore, MD, USA; |
| Abstract: | IntroductionPatients with tuberous sclerosis complex (TSC) frequently present with neurocognitive deficits which may be related to impaired white matter maturation. The purposes of our study were (a) to evaluate the white matter maturation in children and young adults with TSC by comparing the apparent diffusion coefficient (ADC) values of normal-appearing white matter (NAWM) with age-matched healthy controls and (b) to determine the association of NAWM-ADC values with the severity of neurological symptoms in TSC patients. |
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