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| 甲状腺素对豚鼠耳蜗毛细胞的保护作用 | |
| 引用本文： | 金晓杰 赵纪余 等. 甲状腺素对豚鼠耳蜗毛细胞的保护作用[J]. 听力学及言语疾病杂志, 1995, 3(2): 62-64 |
| 作者姓名： | 金晓杰 赵纪余 等 |
| 作者单位： | 上海第二医科大学附属仁济医院耳鼻咽喉科 |
| 摘 要： | 应用耳蜗外淋巴灌流技术、微电极技术及扫描、透射电镜技术，观察先服甲状腺素（10mg)三次后行外淋巴灌流卡那霉素（10^-3g/ml)1小时的豚鼠实验组（T／K）蜗内电位（EP），耳蜗微音电位（CM）和毛细胞的亚微结构变化，并与单纯灌流卡那霉素（10^-3g/ml)的豚鼠对照组（KM）进行比较，发现3组动物EP无明显差异；实验组（T／K）的CM下降较对照组（KM）少，两者有显著差异；实验组动物外毛细胞损伤较对照组动物轻，提示甲状腺素可能直接作用于听毛细胞，减轻卡那霉素对内耳的毒副作用。 |
| 关 键 词： | 外淋巴灌流 甲状腺素 卡那霉素 保护 耳蜗毛细胞 |
A Study on the Mechanism of Protective Effect of Thyroxin in Ototoxicity of Kanamycin in Guinea Pigs |
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| Jin Xiaojie,Zhao Jiyu,Ding Dalian,et al. A Study on the Mechanism of Protective Effect of Thyroxin in Ototoxicity of Kanamycin in Guinea Pigs[J]. Journal of Audiology and Speech Pathology, 1995, 3(2): 62-64 | |
| Authors: | Jin Xiaojie Zhao Jiyu Ding Dalian et al |
| Abstract: | The techniqties of perilymphatic perfusion,microelectrode,scanning electron and transmission electron microscope were used to observe changes of endocochlear potential(EP),cochlear microphonics(CM)and morphologic,which were caused by oral administration of thyroxine orally before the period of perfusion, The results show that there was no difference in EP between two groups,but CM in the experimental group(T/K)decreased more slightly than that of the control group.The damages of outer hair cells in the kanamycin(KM)group were more than those of in the T/K group.It is suggested thyroxin might outer hair cells directly improve their resistence to ototoxicity of KM. |
| Keywords: | Perilymphatic perfusion Thyroxin Kanamycin Protect Cochlear hair cell |
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