抗癫癎药物与大鼠海马CA1区胶质细胞TUNEL阳性表达关系的研究 |
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引用本文: | 王晓鹏,王维平,刘瑞春,耿连霞,吴丽玲,刘惠苗,杨兰,卜志平.抗癫癎药物与大鼠海马CA1区胶质细胞TUNEL阳性表达关系的研究[J].脑与神经疾病杂志,2008,16(3):210-212. |
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作者姓名: | 王晓鹏 王维平 刘瑞春 耿连霞 吴丽玲 刘惠苗 杨兰 卜志平 |
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作者单位: | 河北医科大学第二医院神经内科,石家庄,050000 |
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基金项目: | 河北省自然科学技术基金 |
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摘 要: | 目的:探讨抗癫癎药物对大鼠海马胶质细胞凋亡的影响。方法:35只60天龄SD大鼠随机分为生理盐水组(NS)、戊四氮(PTZ)组、卡马西平组(CBZ)、丙戊酸钠组(VPA)、苯妥英钠组(PHT)、托吡酯组(TPM)、拉莫三嗪组(LTG)7组,起始体重(200±20)g,戊四氮点燃其中6组制作癫癎模型,再给与抗癫癎药物治疗3周,应用TUNEL法观察大鼠海马胶质细胞的阳性表达率。结果:CA1区胶质细胞TUNEL阳性表达:NS组阳性率4.195%,PTZ组阳性率6.536%,CBZ组阳性率4.321%,VPA组阳性率5.587%,4组之间TUNEL阳性表达率差异无显著性(χ2=1.158,P>0.05);PHT组阳性率24.460%,TPM组阳性率21.605%,LTG组阳性率18.902%,三组之间TUNEL阳性表达率差异无显著性(χ2=1.378,P>0.05)。NS组、PTZ组、CBZ组、VPA组与PHT组、TPM组、LTG组之间TUNEL阳性表达率差异有显著性(χ2=70.227,P<0.005)。结论:大鼠癫癎模型经PTH、TPM、LTG治疗后,海马CA1区存在TUNEL阳性胶质细胞。
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关 键 词: | 抗癫癎药物 海马神经胶质细胞 凋亡 戊四氮 |
文章编号: | 1006-351X(2008)03-0210-04 |
修稿时间: | 2007年9月28日 |
The study of relationship between anti-epileptic drug with Hippocampus neuron TUNEL positive express |
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Institution: | WANG Xiao-peng; WANG Wei-ping; LIU Rui-chun; et al.Department of Neurology; The Second Hospital of Hebei Medical University; Shijiazhuang 050000; China; |
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Abstract: | Objective:To explore the relationship of antiepileptic drugs with apoptosis of hippocamp astrocytes.Methods:35 adolecence male Sprague-Dawley rats,weighting(200±20)g,were divided into seven groups randomly :normal control group(NS group),status epileptics group(Pentylenetetrazole,PTZ group),carbamazepine(CBZ)group,valproate sodium(VPA)group,phenytoin(PHT)group,topiramate(TPM)group,lamotrigine(LTG)group.Besides NS group,they were kindling by PTZ,then they were treated by antiepileptic drugs(AEDs).Three weeks... |
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Keywords: | antiepileptic drugs Pentylenetetrazole hippocampus astrocytes apoptosis |
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