利福平乙基纤维素微球的制备及质量评价

分析下丘脑背内侧核（ｎｕｃｌｅｕｓ ｄｏｒｓｏｍｅｄｉａｌｉｓ ｈｙｐｏｔｈａｌａｍｉ， ＮＤＭ）升压反应的机制。 方法：大鼠脑内或静脉注射不同药物，记录血压和心率的变化。结果：（１）谷氨酸（ｇｌｕｔａｍａｔｅ，Ｇｉｎ）注入ＮＤＭ，Ｐ物质注入室旁核（ｎｕｃｌｅｕｓ 　ｐａｒａｖｅｎｔｒｉｃｕｌａｒｉｓ，ＮＰＶ）或延髓头端腹外侧区（ｒｏｓｔｒａｌ　ｖｅｎｔｒｏｌａｔｅｒａｌ　ｍｅｄｕｌｌａ，ＲＶＬ）均引起升压反应；（２）ＮＤＭ升压反应可被双侧ＮＰＶ或ＲＶＬ内注入Ｐ物质拮抗剂衰减，但ＲＶＬ内注入阿托品无此效应；（３）静脉注射酚妥拉明也能使ＮＤＭ升压反应减小，而心得安或甲基阿托品静脉注射对该反应无影响。结论：Ｇｌｕ注入 ＮＤＭ可通过ＮＰＶ（Ｐ物质受体）和ＲＶＬ（Ｐ物质受体）－交感缩血管神经系统引起升压反应。

Development and evaluation of rifampin microspheres with ethylcellulose

Objective and Methods: Rifampin/ ethylcellulose microspheres were developed by inliquid drying method. The content of rifampin in microspheres was measured. Dissolution andscanning electron microscopy were employed to display the characteristic of the microspheres in vitro.Results: The prepared microspheres using seven different comPOsition ratios of ethylcellulose: rifampinin triplicates were round in appearance. The entrapment of rifampin was between 27. 2 % and 64. 8 %.The release of rifampin in various batches of microspheres can be discribed by Hiquchi equation.Conclusion: Rifampin microspheres can be prepared with ethyllcelulose by in-liquid drying method.