伏格特小柳原田综合征的吲哚青绿眼底血管造影观察

目的 探讨利用吲哚青绿血管造影(indocyanine green angiography,ICGA)检查作为伏格特小柳原田(Vogt-Koyanagi-Harada,VKH)综合征临床观察指标的意义。 方法 对26例VKH患者荧光素眼底血管造影(fundus fluorescein angiography,FFA)和ICGA检查资料进行分析。 结果 FFA表现为色素上皮水平多数针尖状渗漏，快速形成多湖状荧光积存。治疗后上述改变很快消失。葡萄膜炎期ICGA表现：①66.7%的患眼为多数灶状弱荧光区域和脉络膜大、中血管荧光影像减少；②70.8%的患眼脉络膜血管扩张；③79.2%的患眼为造影后期显示灶状强荧光区。在病变恢复期，与FFA检查比较，ICGA的异常发现恢复缓慢。 结论 ICGA 可较好提供VKH的脉络膜循环损害的信息，并在评价疗效上有意义。(中华眼底病杂志,2000,16:9-11)

Characteristics Indocyanine green angiography in Vogt-Koyanagi-Harada syndrome

Objective To investigate the cilinical value of indocyanine green angiography(ICGA) in patients with Vogt Koyanagi Harada syndrome(VKH). Methods Fundus fluorescein angiography(FFA) and indocyanine green angiography(ICGA) were used for comparative analyses in 26 cases(52 eyes)of VKH. Results In the acute stage of VKH,FFA revealed the multifocal leakage in the pigment epithelium and the multifocal serous retinal detachment,and the typical FFA manifestations disappeard following treatment.In the acute stage of the disease the ICGA showed:(1)numerous patchy areas of hypofluorescence and decreased flurescence in large and middle choroidal vessels (66.7%); (2)dilatation of the choroidal vessels(70.8%)and(3)in late phase of ICGA,the patchy areas of hyperfluorescence(79.2%).During the recovery stage of the disease,the abnormal undings in ICGA were resolved slower than those found in FFA. Conclusions ICGA may assist in providing valuable informations on choroidal circulation of VKH and be useful in evaluating the curative effects.