早期应用阿托伐他汀对老年性脑梗死患者血清C-反应蛋白的影响

目的:探讨阿托伐他汀对老年性脑梗死患者血清C-反应蛋白(CRP)水平的影响。方法:将70例脑梗死患者随机分为常规治疗组(35例)和阿托伐他汀治疗组(35例),30例健康人为对照组。阿托伐他汀治疗组于常规治疗基础上加用阿托伐他汀40 m g/d,疗程为15 d。两组均于治疗前和治疗结束时测定血清CRP。结果:阿托伐他汀组治疗2周后,CRP较治疗前下降(P<0.05)。常规组治疗前后无明显变化(P>0.05)。结论:在脑梗死早期给予大剂量阿托伐他汀治疗,使CRP水平下降,可能有利于抑制炎症反应、稳定斑块。

Effect of early atorvastatin on the C-reactive protein in patients with cerebral infarction

Objective:To explore the effect of atorvastation on serum C-reactive protein in patients with cerebral infarction.Methods:Seventy patients with cerebral infarction were randomly divided into routine therapy group(35 cases) and atorvastatin group(35 cases).30 healthy subjects were taken as control.In the atorvastatin group,atorvastatin was given 40 mg/d.C-reactive protein(CRP) levels was measured before and after the treatments.Results:After ratorvastatin treatment,the levels of CRP was decreased significantly(P<0.01).Conclusions:Early atorvastatin treatment may be of great benefit to inhibit inflammatory responses,atherosderotic plaque stabilization in patients with cerebral infarction.