| 紫外分光光度法测定替米沙坦胶囊含量及溶出度 |
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| 引用本文： | 郭毅,付焱. 紫外分光光度法测定替米沙坦胶囊含量及溶出度[J]. 中国药房, 2007, 18(7): 538-540 |
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| 作者姓名： | 郭毅 付焱 |
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| 作者单位： | 1. 河北省药品检验所,石家庄市,050011
2. 河北医科大学药学院,石家庄市,050017 |
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| 摘 要： | 目的:建立以紫外分光光度法测定替米沙坦胶囊含量及溶出度的方法。方法:采用紫外分光光度法,以0.1mol·L-1盐酸溶液作为溶剂,测定波长为291nm。结果:替米沙坦检测浓度在2～16μg·mL-1范围内线性关系良好(r=0.9999),平均回收率为99.9%(RSD=0.24%,n=9)。结论:所建立的方法操作简便、结果准确。
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| 关 键 词： | 紫外分光光度法 替米沙坦 含量 溶出度 |
| 文章编号： | 1001-0408(2007)07-0538-03 |
| 修稿时间： | 2006-03-21 |
Determination of the Content and Dissolution of Telmisartan Capsules by Ultraviolet Spectrophotometry |
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| GUO Yi,FU Yan. Determination of the Content and Dissolution of Telmisartan Capsules by Ultraviolet Spectrophotometry[J]. China Pharmacy, 2007, 18(7): 538-540 |
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| Authors: | GUO Yi FU Yan |
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| Abstract: | OBJECTIVE: To establish a method for determining the content and dissolution of Telmisartan Capsules by Ultraviolet spectrophotometry. METHODS: The determination was performed using Ultraviolet spectrophotometry with 0.1mol·L-1 hydrochloric acid solution as solvent. The detection wavelength was set at 291nm. RESULTS: The linear range of telmisartan was 2～16μg·mL-1(r=0.999 9), with average recovery at 99.9% (RSD=0.24%,n=9). CONCLUSION: The method is easy to operate and the results of the determination are accurate. |
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| Keywords: | Ultraviolet spectrophotometry Telmisartan Content Dissolution |
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