Intraocular penetration of liposomal amphotericin B after intravenous injection in inflamed human eyes |
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| Institution: | 1. Laboratory of Microbiology, School of Health Sciences, Faculty of Medicine, University of the Ryukyus, Japan;2. Dept. of Food Microbiology and Molecular Biology, National Institute of Nutrition, Viet Nam;1. Department of Pharmacokinetics, Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto, 860-0082, Japan;2. Division of Pharmacodynamics, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan;3. DDS Research Institute, Sojo University, 4-22-1 Ikeda, Kumamoto, 860-0082, Japan;4. Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, 1-21-1 Toyama, Shinjuku, Tokyo, 162-8655, Japan;5. Department of Clinical Science, Kumamoto University Hospital, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan;6. Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institute of Health, Bethesda, MD, 20892, United States;1. Department of Defense Medicine, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama, Japan;2. Department of Dermatology, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama, Japan;3. Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama, Japan;4. Research Institute for Physical Activity, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka, Japan;5. Department of Otolaryngology, Head and Neck Surgery, Self-Defense Forces Central Hospital, 1-2-24, Ikejiri, Setagaya, Tokyo, Japan;6. Department of General Medicine, Self-Defense Forces Central Hospital, 1-2-24, Ikejiri, Setagaya, Tokyo, Japan;7. Department of General Medicine, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama, Japan;1. Division of Infection Control and Prevention, Osaka University Hospital, 2-15 Yamadaoka, Suita, Osaka, 565-0871, Japan;2. Laboratory for Clinical Investigation, Osaka University Hospital, 2-15 Yamadaoka, Suita, Osaka, 565-0871, Japan;3. Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan |
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| Abstract: | PurposeTo determine the intraocular penetration of amphotericin B (AMPH-B) after an intravenously injection of liposomal amphotericin B (L-AMB) in inflamed human eyes.MethodsSeven eyes of 5 patients with fungal eye diseases (endophthalmitis in 6 eyes and keratitis in 1 eye) were treated with intravenous injections of 100–250 mg/day of L-AMB. Samples of blood, corneal button, aqueous humor, and vitreous humor were collected and assessed for AMPH-B.ResultsThe AMPH-B level in the cornea (604.0 μg/g) of the case with fungal keratitis exceeded the minimum inhibitory concentration. However, the levels in the aqueous and vitreous humors of the cases with fungal endophthalmitis were lower, e.g., 0.02 ± 0.01 μg/ml (0.09% of serum level) in the aqueous humor and 0.05 ± 0.08 μg/ml (0.17% of serum level) in the vitreous humor.ConclusionsThe AMPH-B levels administered intravenously were very low in the aqueous and vitreous humors. Our findings indicate that intravenous L-AMB can be considered only for patients with mild endogenous fungal endophthalmitis, e.g., isolated chorioretinitis without vitreous extensions. |
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| Keywords: | Liposomal amphotericin B Intraocular penetration Fungal eye disease |
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