原发性肝癌经动脉化疗栓塞预防性应用抗生素前瞻性研究

目的 探讨原发性肝癌经动脉化疗栓塞是否需要预防性应用抗生素。方法 对60例择期术前无感染原发性肝癌患者随机分为两组:一组术前单剂量预防应用先锋霉素Ⅴ;另一组无预防应用抗生素。比较两组术后感染率。结果 不预防性应用组感染率为3.4%(1/29),预防性应用抗生素组感染率为3.2%(1/31),两组术后感染率无显著差异(P>0.05)。结论 术前无感染原发性肝癌患者经动脉化疗栓塞没有必要使用抗生素预防感染。

Necessity of prophylactic antibiotics in patients with primary liver cancer undergoing transcatheter arterial chemoembolization: a prospective study

Objective To investigate the necessity of prophylactic administration of antibiotic in patients with primary liver cancer undergoing transcatheter arterial chemoembolization (TACE). Methods Sixty patients without preoperative infection were randomized into two groups to receive a single dose of cefazolin (PA group) prior to TACE or no prophylactic antibiotics (NONE group). The incidence of postoperative infection was compared. Results The incidence of postoperative infection was 3.4% (1/29) in NONE group and 3.2% (1/31) in PA group, without significant difference between the two groups (P>0.05). Conclusion Prophylactic antibiotics are not necessary for patients with primary liver cancer prior to TACE.