可溶性细胞间黏附分子-1与支气管哮喘病情程度的关系

目的探讨可溶性细胞间黏附分子－1（sICAM－1）与支气管哮喘发作及其病情严重程度的相关性。方法采用ELISA方法测定134例不同时期支气管哮喘患者及健康志愿者血清sICAM-1水平，同时对支气管哮喘急性发作期患者进行肺功能测定。结果63例急性发作期支气管哮喘患者血清sICAM-1[（298．05±52．33）ng／L]水平较缓解期患者[（213．36±16．88）．g／L]及健康志愿者[（117．83±13．23）ng／L]明显升高，并且随哮喘病情加重其值有明显升高；急性发作期患者肺功能第一秒用力呼吸量（FEV．％）值与血清slCAM-1呈明显负相关。结论slCAM-1是支气管哮喘发病中重要的黏附分子，可作为判断病情严重程度的指标之一。

The role of soluble intercelluar adhesion molecule-1 in the pathogenesis of bronchial asthma

Objective To study the role of soluble intercellular adhesion molecule-1 ( sICAM-1 ) in the pathogenesis of adults bronchial asthma and analyze the relationship between the level of sICAM-1 and the severity of bronchial asthma.Methods Serum levels of sICAM-1 in 134 cases with different periods of bronchial asthma patients and healthy volunteers were measured by ELISA and pulmonary functions of acute asthma patients were determined by pulmonary function analyzer. Results Serum sICAM-1 levels in 63 cases of acute asthma patients were increased significantly when compared with those in remission asthma patients and healthy volunteers and its value was increased significantly with the exacerbation of asthma;A negatively correlation between FEV1％ of pulmonary function and serum sICAM-1 level in patients with acute asthma was found in this study. Conclusion sICAM-1 was one of the important adhesion molecules in the pathogenesis of bronchial asthma. It could be used as one indicator of disease severity and guide the drug application in clinic.