甲状腺功能减退症患者激素替代治疗前后血脂和心肌酶谱的变化及意义

目的观察甲状腺功能减退症（甲减）患者激素替代治疗前后血脂和心肌酶谱的变化及意义。方法检测72例甲减患者（观察组）治疗前后和60例健康对照组血清中总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL—C）、天门冬氨酸转氨酶（AST）、乳酸脱氢酶（LDH）、α-羟丁酸脱氢酶（HBDH）和肌酸肌酶同工酶（CKMB）水平。结果观察组治疗前TC、TG和LDL-C水平均明显高于对照组（均P〈0．05），而治疗后水平明显下降（均P〈0．05），略高于对照组，但差异无统计学意义（均P〉0．05）。观察组治疗前AST、LDH、HBDH和CKMB水平明显高于对照组（均P〈0．05），而治疗后AST、LDH、HBDH和CKMB水平明显下降（均P〈0．05），治疗后AST、LDH、HBDH和CKMB水平与对照组比较，差异无统计学意义（均P〉0．05）。结论甲减患者经激素替代治疗后血脂和心肌酶谱基本恢复正常，对于防治心血管疾病具有重要意义。

The changes and significance of blood fat and myocardial enzymes in patients with hypothyroid myopathy before and after substitutional treatment

Objective To observe the changes and significance of blood fat and myocardial enzymes in patients with hypothyroid myopathy before and after substitutional treatment.Methods The levels of TC, TG, LDL-C,AST, LDH, HBDH and CKMB were detected in 72 cases with hypothyroid myopathy patients before and after substitutional treatment and 60 healthy controls. Results The levels of TC,TG and LDL-C in hypothyroid myopathy patients before substitutional treatment were significantly higher than those in control group ( all P ＜ 0. 05 ), and then significantly low after treatment,which had no significant difference with control group( all P ＞0. 05). The levels of AST,LDH,HBDH and CKMB in hypothyroid myopathy patients before substitutional treatment were significantly higher than those in control group( all P ＜ 0. 05 ) ,and then significantly low after treatment,which had no significant difference with control group( all P ＞0. 05). Conclusion The levels of blood fat and myocardial enzymes were significantly increased in hypothyroid myopathy patients, and recovery to normal after substitutional treatment.