| Megalin和cubilin生理表达与相关疾病 |
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| 引用本文： | 苗秀明,翟效月. Megalin和cubilin生理表达与相关疾病[J]. 解剖科学进展, 2007, 13(2): 176-179 |
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| 作者姓名： | 苗秀明 翟效月 |
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| 作者单位： | 辽宁医学院组织胚胎学教研室,辽宁锦州121001;中国医科大学组织胚胎学教研室,辽宁沈阳110001 |
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| 摘 要： | Megalin和cubilin是两个大分子、多配体的受体糖蛋白,广泛分布于极化的上皮细胞内。在体内,尤其在肾脏,它们通过胞吞作用在介导蛋白质和许多维生素的吸收方面发挥着重要的生理功能。两受体任何一方功能异常或缺失会出现明显的蛋白尿和某些肾病,因此两种受体的病理生理作用越来越受到人们的关注。本文就Megalin和cubilin的生理功能及其相关疾病简要综述。
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| 关 键 词： | Megalin cubilin 生理作用 表达 相关疾病 Function Disease 病理 肾病 蛋白尿 功能异常 生理功能 吸收 多维生素 蛋白质 胞吞作用 肾脏 胞内 上皮 极化 |
| 文章编号： | 1006-2947（2007）02-0176-04 |
| 修稿时间： | 2007-01-09 |
Physiological Function of MegalinCubilin and Associated Disease |
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| MIAO Xiu-ming,ZHAI Xiao-yue. Physiological Function of MegalinCubilin and Associated Disease[J]. Progress of Anatomical Sciences, 2007, 13(2): 176-179 |
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| Authors: | MIAO Xiu-ming ZHAI Xiao-yue |
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| Affiliation: | 1. Department of Histology and Embryology, Liaoning Medical college, Liaoning Jinzhou 121001, China; 2. Department of Histology and Embryology,China Medical University,Liaoning Shenyang 110001 , China |
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| Abstract: | Megalin and cubilin are two large, multiligand glycoprotein receptors expressed extensively in polarised epithelial cells. In vivo, especially in kidney, they were expressed in the endocytic paths, playing important roles in facilitating reabsorption of certain glomerular filtrated plasma proteins and some vitamin.Absence or dysfunction of either receptor is associated with singnificant proteinuria or certain renal disease. Thus, more and more, the pathophysiological implication of both receptors is being concerned. The aim of the present article is to briefly review the physiological function of megalin cubilin and its associated disease. |
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