| 薄层色谱法测定地红霉素中的有关物质 |
| |
| 引用本文： | 何维英,高红,李静.薄层色谱法测定地红霉素中的有关物质[J].中国生化药物杂志,2003,24(5):246-247. |
| |
| 作者姓名： | 何维英 高红 李静 |
| |
| 作者单位： | 中国医学科学院、协和医科大学,医药生物技术研究所,北京,100050 |
| |
| 摘 要： | 目的采用薄层色谱法检查地红霉素中的有关物质。方法地红霉素供试品经无水甲醇溶解后 ,以正己烷 二氯甲烷 甲醇 浓氨水 (2∶3∶0 .8∶0 .0 6)为展开剂 ,在硅胶GF2 5 4薄层板上展开 ,以硫酸显色后观察。结果确立供试品有关物质限度。结论此法简便、灵敏、准确 ,可作为地红霉素有关物质的快速测定
|
| 关 键 词： | 地红霉素 有关物质 薄层色谱法 |
| 文章编号： | 1005-1678(2003)05-0246-02 |
| 修稿时间： | 2002年12月30 |
Study on the determination of related substances in dirithromycin by thin-layer chromatography |
| |
| HE Wei-ying,GAO Hong,LI Jing.Study on the determination of related substances in dirithromycin by thin-layer chromatography[J].Chinese Journal of Biochemical Pharmaceutics,2003,24(5):246-247. |
| |
| Authors: | HE Wei-ying GAO Hong LI Jing |
| |
| Abstract: | PurposeThe aim is to control qualitatively t he rel ated substances in dirithromycin by thin-layer chromatography (TLC).Met hodsSample preparation: dirithromycin dissolved with ethanol, st ationary phase: GF 254 silicon gel, mobile phase: n-Hexane-dichlorometha ne- methanol-ammonia water(2∶3∶0.8∶ 0.06 ), sulfuric acid as colorate reagent.ResultsThe impurity limit was obtained. ConclusionThis method is simple,sensitive and accurate.It can be used for rapid quality control of the related substances in dirithromy cin. |
| |
| Keywords: | dirithromycin related substances thin-layer chro matography |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
