陶瓷样异种骨复合骨髓异位成骨的实验研究

目的了解陶瓷样异种骨（ＣＸＢ）与骨髓（ＢＭ）复合移植的成骨作用。方法将ＣＸＢ与ＢＭ复合及单纯ＣＸＢ植入兔的骶棘肌内，术后２、４、８、１２、１６及２４周取出植入材料作组织学及组织化学检查，观察植入材料的成骨作用。结果ＣＸＢ与ＢＭ复合植入后２周开始有软骨和新骨生成，以后软骨逐渐钙化成骨，８周时出现髓腔，并随植入时间的延长，新骨生成增多，成骨更为典型。而单纯ＣＸＢ植入后无新骨或软骨形成。结论ＣＸＢ与ＢＭ复合移植通过骨传导、骨诱导及提供成骨细胞或成软骨细胞而成骨，是一种理想的骨移植替代材料，可望在临床上用于骨缺损的修复。

CERAMIC-LIKE XENOGENEIC BONE COMBINING WITH BONE MARROW

OBJECTIVE: This experimental study was aim to investigate the osteogenesis of ceramic-like xenogeneic bone (CXB) combining with bone marrow (BM). METHODS: The CXB combining BM was implanted into the sacrospinalis muscle of rabbits, and CXB implanted alone was used as control. Eighteen Japanese rabbits with long ear were used. The size of CXB was 5 mm x 5 mm x 5 mm, and the implanted materials were taken out at 2, 4, 8, 12, 16 and 24 weeks after implantation. The histological and histochemical characteristics were investigated. RESULTS: There existed cartilage and new bone in the groups of CXB combining BM in 2 weeks. Later, be cartilage turned out to the bone and in eight weeks the medullary cavity appeared. However, as the time went on, new bone formation increased and typical osteogenesis could be found. While in the groups of CXB alone, no formation of new bone or cartilage was found. CONCLUSION: The implantation of CXB combined with BM could result in new bone formation in the way of osteoconduation, osteoinduction, and providing, osteoblasts or chondroblasts. It could be an ideal bone substitute, and its clinical use in future seemed very hopeful.