格雷夫斯病患者血清促甲状腺激素受体抗体检测的临床意义

目的 通过测定格雷夫斯病(Graves病,GD)患者血清促甲状腺激素受体抗体(TRAb)水平,了解其临床意义.方法 采用放射受体分析方法(RRA)对64例初诊GD患者,57例经抗甲状腺药物(ATD)治疗缓解的GD患者,32例经ATD治疗未缓解的患者,35例GD复发患者,48例未复发患者及30例健康体检者分别进行TRAb及三碘甲状腺原氨酸(TT3)、甲状腺素(TT4)、游离甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)的测定.结果 初诊组及复发组TRAb水平分别为(35.02±5.46)U/L、(26.11±3.72)U/L,均显著高于健康对照组的(1.51±0.28)U/L(P＜0.01);缓解组TRAb水平(7.85±1.29)U/L,低于未缓解组的(19.28±4.25)U/L,但显著高于正常对照组(P＜0.01);浸润性突眼者血清TRAb水平(29.73±6.19)U/L,明显高于非浸润性突眼者的(12.69±3.42)U/L(P＜0.01).结论 检测血清TRAb水平在GD发病、进展及复发具有重要的临床意义.

Clinical significance of detecting serum thyrotropin receptor antibody levels in patients with Graves disease

Objective To explore the clinical significance of thyrotropin receptor antibody（TRAb） in patients with Graves disease.Methods Serum TRAb and thyroid hormones were detected by radio receptor assay（RRA） in the following subjects：group A,64 cases of recently diagnosed Graves diease;group B,57 cases of alleviated patients after anti-thyroid treatment;group C,32 cases of non-alleviated ones;group D,35 cases of relapsing Graves disease after previous successful treatment;group E,48 cases of non-relapsing ones.30 cases of normal pepole.Results The TRAb levels of group A（35.02±5.46） U/L and group D（26.11±3.72） U/L were both significantly higher than that in group F（1.51±0.28）U/L（P0.01）.The levels of TRAb in group B（7.85±1.29） U/L was lower than that in group C（19.28±4.25） U/L,but signicantly higher than that in group F（P0.01）.The Graves patients with infiltrative exophthalmos had higher TRAb level（29.73±6.19） U/L than that of patients with non-infiltration exophthalmos（12.69±3.42） U/L（P0.01）.Conclusion The detection of serum TRAb level is of great clinical significance in the course of Graves diease.