姜黄素对不稳定型心绞痛患者血清单核细胞趋化蛋白1、超敏C反应蛋白水平的影响

目的 观察姜黄素对不稳定型心绞痛(UAP)患者血清单核细胞趋化蛋白1(MCP-1)和超敏C反应蛋白(hsCRP)水平的影响.方法 UAP患者共48例,随机分为对照组(n=23)和治疗组(n=25).治疗组在常规治疗的基础上加用姜黄素口服,对照组在常规治疗基础上给予辛伐他汀口服.另设健康组(n=2 0)为周期故城县体检者,年龄、性别等一般资料与上述两组差异无统计学意义.分别用酶联免疫吸附测定法和免疫比浊法测定两组治疗前、第4周血清MCP-1和hsCRP水平的变化.结果 与健康组比较,UAP各组血清MCP-1和hsCRP水平显著增高,MCP-1(138±14)ng/L、(144±15)ng/L vs (55±12)ng/L;hsCRP(8.13±1.06)mg/L、(8.83±1.23)mg/L vs(2.92±0.93)mg/L(均P＜0.01).与治疗前比较,治疗后UAP各组血清MCP-1和hsCRP水平有显著下降,MCP-1(138±14)ng/L vs(99±7)ng/L、(144±15)ng/L vs(76±7)ng/L;hsCRP(8.13±1.06)mg/L vs(5.90±0.68)mg/L、(8.83±1.23)mg/L vs(4.10±0.74)mg/L(均P＜0.01).与对照组比较,治疗组治疗后血清MCP-1水平和hsCRP水平显著下降,MCP-1(99±7)ng/L vs(76±7)ng/L,hsCRP(5.90±0.68)mg/L vs(4.10±0.74)mg/L(均P＜0.01).结论 UAP患者应用姜黄素可减轻炎症反应.

Effects of curcumin on serum mononcyte chemoattractant protein-1 and high sensitivity C-reactive protein in patients with unstable angina pectoris

Objective To observe the effects of curcumin on serum mononcyte chemoattractant protein-1（MCP-1） and high sensitivity C-reactive protein（hsCRP） in patients with unstable angina pectoris（UAP）.Methods Forty-eight patients with UAP were divided into control group（n=23） and curcumin group（n=25）.The curcumin group was given curcumin and traditional treatment,the control group was given simvastatin and traditional treatment.Another healthy group（n=20） was selections in match with age,sex and other indexes from body check at the same time.Serum MCP-1 and hsCRP were measured by enzyme-linked immunosorbent assay and turbidmetric before and four weeks after oral administration of curcumin.Results In comparison with healthy group,the levels of serum MCP1 and hsCRP in patients with UAP were significantly increased,MCP-1（138±14） ng/L or（144±15） ng/L vs（55±12） ng/L;hsCRP（8.13±1.06） mg/L or（8.83±1.23） mg/L vs（2.92±0.93） mg/L（all P0.01）.A significant decreased serum MCP-1 and hsCRP were observed four weeks after curcumin was taken in patients with UAP,MCP-1（138±14） ng/L vs（99±7） μg/L and（144±15） ng/L vs（76±7） ng/L;hsCRP（8.13±1.06） mg/L vs（5.90±0.68） mg/L and（8.83±1.23） mg/L vs（4.10±0.74） mg/L（all P0.01）.In comparison with control group,the levels of serum MCP-1 and hsCRP in patients taking curcumin were significantly decreased,MCP-1（99±7） ng/L vs（76±7） ng/L;hsCRP（5.90±0.68） mg/L vs（4.10±0.74） mg/L（all P0.01）.Conclusion Curcumin could alleviate inflammatory reaction in patients with UAP.