血清apelin水平与2型糖尿病并颈动脉粥样硬化的关系

目的 探讨血清apelin水平与2型糖尿病(T2DM)惠者并颈动脉粥样硬化的关系.方法 分别测定正常时照组(30例)、T2DM无颈动脉粥样硬化组(简称:T2DM组,35例)、T2DM伴颈动脉粥样硬化组(35例)的体质量指数(BMI),空腹血糖(FPG),糖化血红蛋白(HbA1c),血脂,空腹胰岛素(FINS),胰岛素抵抗指数(HOMA-IR)等,采用酶联免疫吸附法(ELISA)测定血清apelin水平.结果 与正常对照组比较,血清apelin水平在T2DM组明显升高,(53.79±9.17)μg/L vs(44,44±9,20)μg/L(P<0.01);与T2DM组比较,血清apelin水平在T2DM伴颈动脉粥样硬化组也升高,(61.52±5.18)μg/L vs(53.79±9.17)μg/L(P<0.01).偏相关分析显示,血清apelin与HOMA-IR、FPG、总胆固醇(TC)呈正相关(r=0.486,0.400,0.491,P<0.05,P<0.01).logistic回归示:apelin、HOMA-IR是T2DM患者颈动脉粥样硬化的危险因素.结论 T2DM颈动脉粥样硬化患者的血清apelin水平升高,且与In、(HOMA-IR),FPG、TC呈正相关,推测apelin可能参与构成胰岛素抵抗综合征和动脉粥样硬化的病理生理基础.

Correlation between serum apelin level and type 2 diabetes mellitus with atherosclerosis

Objective To investigate the relationship between serum apelin level and type 2 diabetes mellitus （T2DM） patients with atherosclerosis. Methods Totally 100 subjects were enrolled as normal control group （30 cases）, T2DM no atherosclerosis group（in short, T2DM group, 35 cases）, T2DM with atherosclerosis group（35 cases）. Body mass index（BMI）,waist hip ratio（WHR）,fasting plasma glucose（FPG）, HbA1C, blood lipids, insulin resistance index（HOMA-IR） were assayed in all the subjects. Later serum apelin level was detected by enzyme-linked immunosorbent assay assay. Results Compared with that of normal control group,serum apelin level was significantly higher in T2DM group （53.79±9.17） μg/L vs （44.44±9.20） μg/L（ P 〈0.01）;compared with the T2DM group, serum apelin level in T2DM with carotid atherosclerosis was also significantly higher （61.52±5.18） μg/L vs （53.79± 9.17） μg/L （P〈0.01）. Partial correlation analysis showed that serum apelin level was positively correlated with HOMA-IR,FPG,TC（ r =0. 486,0. 400,0. 491, P 〈0.05, P 〈0.01 ）. Logistic regression analysis showed that apelin and HOMA IR were the risk factors for T2DM with atherosclerosis. Conclusion Serum apelin level in T2DM patients with atherosclerosis increases and is positive correlated with HOMA-IR,FPG, TC. Apelin might be involved in insulin resistance syndrome and constitutes the atherosclerotic pathological physiological basis.