吸烟与凝血纤溶功能相关性研究

目的探讨吸烟者凝血纤溶机制的改变规律,研究吸烟对心脑血管疾病影响的途径。方法使用Sysmex-CA-1500型血凝仪检测150例吸烟者（按吸烟程度不同分为3组）与50例对照者血小板、凝血酶原时间（PT）,活化部分凝血活酶时间（APTT）,凝血酶时间（TT）、纤维蛋白原（FIB）,组织纤溶酶原激活物（t-PA）、D-二聚体（D-D）的含量。结果与对照组相比,吸烟组PLT、PT、APTT、TT,t-PA、D-D均下降,FIB、PAI增高（P〈0.05）。结论重度吸烟组与轻度吸烟组相比较呈现梯度效应（P〈0.05）。吸烟可引起血液系统呈现相对高凝状态并出现继发性纤溶亢进,是心血脑管疾病形成的重要危险因素。

The relevance research for between smoking and coagulation fibrinolytic function

Objective Probe into smoker′s change rule in the mechanism coagulation and fibrinolytic,research the route which affects to brain or heart blood vessel disease in smoking.Methods Use the blood congeal apparatus SysmexCA-15000 to measure 150 smokers（divide into three groups differently according to the intensity of smoking） and 50 contrast persons content of platelet,prothrombin time（PT）,activated partial thromboplastin time（APTT）,thrombin time（TT）,fibrinogen（FIB）,tissue type plasminogen activator（t-PA）,D-dimer（D-D）.Results Compared with contrast group,smoking group PLT,PT,APTT,TT,t-PA,D-D drop,FIB,PAI increase（P0.05）.Conclusion The specific weight smoking group compares with the mild smoking group presents the gradient effect（P0.05）.Smoking may cause the blood systema to present relatively high congeals condition and appears secondary hyperfunction in fibrinolytic,it is important dangerous factor which induce the heart and brain blood vessel disease.