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| 串联四极杆质谱法测定中药降糖制剂中掺入吡格列酮的研究 | |
| 引用本文： | 邱颖姮, 梁智渊, 刘中博, 王铁杰, 李军. 串联四极杆质谱法测定中药降糖制剂中掺入吡格列酮的研究[J]. 中国现代应用药学, 2008, (3): 247-248. |
| 作者姓名： | 邱颖姮 梁智渊 刘中博 王铁杰 李军 |
| 摘 要： | 目的 建立检测中药降糖制剂中非法掺入的吡格列酮专属性方法.方法 采用串联四极杆质谱法.通过相对分子质量、二级质谱碎片信息二方面信息,对中药降糖制剂的提取液进行串联四极杆质谱分析.通过与对照品的质谱行为相比较,对中药降糖制剂中非法掺入的合成降糖药进行定性鉴别.结果 在34 种受试中药降糖制剂中,2 种被检测到掺有吡格列酮.结论 该方法选择性强,灵敏度高,可作为分析检测中药降糖制剂中非法掺入吡格列酮的比较有效方法. |
| 关 键 词： | 中药降糖制剂 吡格列酮 串联四极杆质谱法 |
Detection of Pioglitazone Illegally Mixed into Traditional Chinese Medicine Antidiabetic Preparations by the Quadrupole Mass Spectrometry Method |
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| QIU Ying-heng, LIANG Zhi-yuan, LIU Zhong-bo, WANG Tie-jie, LI Jun. Detection of Pioglitazone Illegally Mixed into Traditional Chinese Medicine Antidiabetic Preparations by the Quadrupole Mass Spectrometry Method[J]. Chinese Journal of Modern Applied Pharmacy, 2008, (3): 247-248. | |
| Authors: | QIU Ying-heng LIANG Zhi-yuan LIU Zhong-bo WANG Tie-jie LI Jun |
| Abstract: | OBJECTIVE To develop a specific method for the identification of pioglitazone illegally added into traditional Chinese medicine antidiabetic preparations.METHODS The quadrupole mass spectrometry method was used.After separated by mass spectrometry,the org |
| Keywords: | traditional Chinese medicine antidiabetic preparations pioglitazone quadrupole mass spectrometry |
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