Effect of consumption of chicory inulin on bowel function in healthy subjects with constipation: a randomized,double-blind,placebo-controlled trial

Constipation is among the most common health impairments in Western countries. This study aimed to determine the effect of the chicory-derived fermentable dietary fiber Orafti^® Inulin on stool frequency in healthy subjects with constipation. The study was conducted according to recent guidance documents for investigating bowel function and used a randomized, double-blind, placebo-controlled, cross-over design with a 2-week wash-out phase. Each study period comprised a run-in phase followed by 4 weeks daily intake of 3?×?4g inulin or maltodextrin (placebo). Forty-four healthy volunteers with constipation documented stool frequency and consistency, gastrointestinal characteristics and quality of life. Consumption of Orafti^® Inulin significantly increased stool frequency compared to placebo (median 4.0 [IQR 2.5–4.5] versus 3.0 [IQR 2.5–4.0] stools/week, p?=?0.038). This was accompanied by a softening of stools and trend toward higher satisfaction versus placebo (p?=?0.059). In conclusion, Orafti^® Inulin was effective in volunteers with chronic constipation and significantly improved bowel function.

Clinical trial registration: This trial was registered at clinicaltrials.gov as NCT02548247.