Angiotensin II type 1 receptor antagonists inhibit cell proliferation and angiogenesis in breast cancer |
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| Authors: | Xuesong Chen Qingwei Meng Yanbin Zhao Meiyan Liu Dandan Li Yanmei Yang Lichun Sun Guangjie Sui Li Cai Xiaoqun Dong |
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| Affiliation: | 1. Department of Internal Medical Oncology, The Third Affiliated Hospital of Harbin Medical University, Harbin 150040, Heilongjiang Province, China;2. Cancer Research Institute, Harbin Medical University, Harbin 150040, Heilongjiang Province, China;3. Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, The University of Rhode Island, Pharmacy Building, 7 Greenhouse Road, Kingston, RI 02881, USA |
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| Abstract: | Angiotensin II type 1 receptor (AT1R) promotes tumor invasion, migration, metastasis and angiogenesis. We explored the potential antitumor effects of AT1R antagonists in breast cancer. We found that angiotensin II promoted cell proliferation and upregulated the expression of vascular endothelial growth factor A (VEGF-A) in MCF-7 cells. Losartan downregulated the expression of VEGF-A in MCF-7 cells treated with angiotensin II. Candesartan downregulated the expression of VEGF-A in mice bearing MCF-7 xenografts and inhibited tumor growth and angiogenesis. AT1R and VEGF-A expression correlated with increased microvascular density in 102 breast cancer patients. Our data suggest that AT1R antagonists might be useful to suppress breast cancer by inhibiting the angiotensin II. |
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