(1) Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands;(2) Departments of Psychiatry and Neuroscience, Erasmus MC, Rotterdam, The Netherlands
Abstract:
Background
In primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) fatigue is a major clinical problem. Abnormal amino acid (AA) patterns have been implicated in the development of fatigue in several non-hepatological conditions but for PBC and PSC no data are available. This study aimed to identify abnormalities in AA patterns and to define their relation with fatigue.