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| 提高伊马替尼对慢粒白血病敏感性的方法 | |
| 引用本文： | 董奇星. 提高伊马替尼对慢粒白血病敏感性的方法[J]. 国际病理科学与临床杂志, 2011, 31(3): 269-273. DOI: 10.3969/j.issn.1673-2588.2011.03.017 |
| 作者姓名： | 董奇星 |
| 作者单位： | 中南大学药学院,长沙,410013;中南大学,湘雅医院药剂科,长沙,410008 |
| 摘 要： | 随着伊马替尼耐药机制的不断阐明,出现了许多应对耐药的策略.其中提高慢性粒细胞白血病(chronic myeloid leukemia,CML)对伊马替尼敏感性是研究较多的领域,主要方法有提高细胞内伊马替尼的药物浓度、调节信号通道、下调细胞凋亡抑制因子的表达等. |
| 关 键 词： | 慢性粒细胞白血病 伊马替尼 敏感性 |
Way to enhance the sensitivity of imatinib to chronic myeloid leukemia |
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| DONG Qixing. Way to enhance the sensitivity of imatinib to chronic myeloid leukemia[J]. Journal of International Pathology and Clinical Medicine, 2011, 31(3): 269-273. DOI: 10.3969/j.issn.1673-2588.2011.03.017 | |
| Authors: | DONG Qixing |
| Affiliation: | DONG Qixing1,2,QIN Qun2(1.School of Pharmacy,Central South University,Changsha 410013,2.Department of Pharmacy,Xiangya Hospital,Changsha 410008,China) |
| Abstract: | With the progress in elucidating the resistant mechanism of imatinib,reduction of imatinib resistance becomes possible.There are many strategies to increase the sensitivity of imatinib to chronic myeloid leukemia(CML),such as raising the intracellular drug concentration,regulating the signal pathway and inhibiting the expression of apoptotic depressors. |
| Keywords: | chronic myeloid leukemia imatinib sensitivity |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |