膀胱移行细胞癌患者血清骨形成蛋白-2和血管内皮生长因子水平变化

目的：检测骨形成蛋白-2和血管内皮生长因子水平在膀胱移行细胞癌患者血清中的水平。方法：采用ELISA法检测20例健康人、58例膀胱移行细胞癌患者术前的血清BMP-2和VEGF的含量,评价二者在膀胱移行细胞癌发生发展中的意义。结果：膀胱移行细胞癌患者血清中BMP-2和VEGF的水平明显高于健康人,并与肿瘤的浸润深度和分化程度及淋巴结转移、远处转移和临床病理分期密切相关（P〈0.05）,且两者存在明显相关性（P〈0.05）。结论：检测膀胱移行细胞癌患者血清中VEGF、BMP-2的水平,有助于临床诊疗和预后评估。

Detection of Serum BMP-2 and VEGF in Patients with Transitional Cell Carcinoma of Bladders

Objective To detect serum bone morphogenetic protein-2（BMP-2） and vascular endothelial growth factor（VEGF） in patients with bladder transitional cell carcinoma and investigate the correlation of pathologic grade and clinical stage with the expression level. Methods Serum BMP-2 and VEGF levels in 58 preoperative patients of bladder transitional cell carcinoma and 20 healthy people controls were measured by sandwich-ELISA. Results The serum levels of BMP-2 and VEGF in the bladder transitional cell carcinoma were significantly higher than those of controls. Elevated BMP-2 and VEGF levels were associated with the invasion of tumor, degree of differentiation, lymph node metastasis, distant metastasis and clinical pathologic staging（P〈0.05） but not associated with patientsor sex. There was no significant difference between the serum BMP-2 and VEGF levels in healthy serum（P〉0.05）but was significantly different in the serum of bladder transitional cell carcinoma（P〈0.05）Conclusion BMP-2 and VEGF participate in tumor progress, closely related with tumor invasion and metastasis. Serum BMP-2 and VEGF might be useful on clinical diagnosis, treatment and prognosis evaluation of bladder transitional cell carcinoma.