肾移植术后长期存活患者群体反应性抗体的研究

目的研究肾移植术后移植肾长期存活与群体反应性抗体(PRA)的关系。方法对2011年6月至2012年6月时已超过10年存活的377例肾移植患者进行群体反应性抗体检测。采用酶联免疫吸附试验(ELISA)法检测肾移植患者群体反应性抗体。结果 377例存活大于10年以上肾移植患者中,301例患者PRA阴性,76例患者PRA阳性。男性与女性患者间PRA阳性产生的频率具有显著性差异(χ2=5.85,P<0.025)。PRA阴性患者移植肾功能正常率明显高于PRA阳性患者,差异有显著性(χ2=179.26,P<0.0001)。结论男性肾移植患者产生抗HLA抗体的几率高于女性;PRA阳性影响移植肾长期存活。

Correlation study between long term survival and panel reaction antibody in patients with renal transplantation

Objective To study the relationship of panel reaction antibody （PRA） and long term survival in renal transplantation patients. Methods PRA expression of serum was examined in 377 recipients of more than 10 years after renal transplantation using enzyme linked immunosorbent assay from June 2011 to June 2012. Results There were 301 recipients with PRA negative result and 76 recipients with PRA posi- tive result among 377 renal transplant patients of past 10 years. There is significant difference in PRA positive incidence between males and female recipients（ X2 = 5.85, P 〈0. 025 ）. The incidence of renal function to descend in recipients with PRA positive result was significantly higher than that in recipients with PRA negative result （ X2 = 179.26, P 〈 0. 0001 ）. Conclusion The incidence of PRA production was higher in male re- cipients than that in female recipients of renal post - transplant. Patients with PRA positive result will influence the long term survival after renal transplantation.