COPD患者运动康复治疗前后系统性炎症反应的随访研究

目的探讨运动康复对稳定期慢性阻塞性肺疾病(COPD)患者全身炎性反应的影响。方法选择经肺功能测定属于GOLDⅡ～Ⅲ级的确诊COPD病例15例,接受共48周强化及非强化运动训练。在试验前、第一次强化训练后及完成48周运动训练后测定患者相关全身炎性反应指标TNF-α、IL-8、IL-6和IL-10。结果①15例COPD患者全部完成48周运动康复训练;②COPD患者首次强化运动后与运动前比较,血清TNF-α、IL-8、IL-6、IL-10水平无显著变化(P值均>0.05)。③COPD患者经过48周系统运动训练后与运动前比较,血清TNF-α、IL-8水平下降,IL-10水平升高,差异有显著性统计学意义(P值均<0.05﹚;血清IL-6水平无显著变化(P>0.05)。结论①系统运动训练有助于改善COPD患者的全身炎症反应水平;②单次强化运动训练对稳定期中重度COPD患者全身炎症反应无显著影响。

Rehabilitation therapy and systemic inflammatory reaction in patients with COPD: a follow-up study

Objective To investigate the effects of pulmonary rehabilitation on systemic inflammation reaction in patients with stable chronic obstructive pulmonary disease （COPD）. Methods Fifteen stable COPD patients （ GOLDⅡ-Ⅲ ） entered into 48 weeks of rehabilitation pro- gram. Serum levels of tumor necrosis factor -α（ TNF -α） , interleukin 6 （ IL - 6 ） , interleukin （ IL - 8 ） , and interleukin 10 （ IL - 10 ） were ana- lyzed before and after the program, and after the first strengthening exercise training. Results Compared with the level before program, the levels of TNF - a, IL - 6, IL - 8 and IL - 10 did not change significantly after the first strengthening exercise training （ all P 〉 0.05 ） ; however, the levels of serum TNF - cLand IL - 8 were markedly decreased, while the level of IL - 10 was significantly increased after 48 weeks exercise training （ all P 〈 0.05 ）. There was no significant change in the level of IL - 6 before and after the rehabilitation program （ P 〉 0.05 ）. Conclusion The systemic inflammation reaction can be improved by systemic exercise training. Single strengthening exercise does not significantly impact on systemic inflammation reaction in COPD patients.