梅毒螺旋体血清学监测及流行特征

目的通过梅毒血清学实验检测结果分析,了解本区域梅毒流行特征和方法学比较。方法依据2005～2007年我院进行梅毒血清学检测结果和2000年中国卫生部防疫司颁布的性病诊断标准,对临床梅毒进行分期;对阳性患者进行流行病学调查,同时评价TRUST、TP-ELISA和TPPA法特异性与敏感性。结果2005年梅毒血清学阳性率为2.7%,2006年为4.0%,2007年为8.7%;3年来Ⅰ期梅毒分别占55.9%、73.9%和61.3%,Ⅱ期梅毒分别占33.8%、20.4%和32.1%,Ⅲ期梅毒相对较少,隐性梅毒分别为8.8%、5.0%和6.0%;TRUST、ELISA和TPPA法敏感性分别为72%、87%和68%,特异性分别为88%、95%和100%。梅毒患者中男女比例为0.63：1,文化程度是初中和小学毕业占62%,其它38.0%,年龄分布主要在青壮年,职业分布是服务业和打工者占76.0%,其它占24.0%为主,婚姻状况已婚者占65.0%。结论梅毒血清学试验中敏感性ELISA法较高,特异性TPPA较高。

Study on serological test and epidemiology in syphilis

Objective To eliminate Microspironema pallidum by studying the serological test and the message of epidemiology in syphilis. Methods The message of epidemiology in syphilis were provided by syphilis patients from 2005 to 2007 in our hospital. The three serological tests including TRUST ,ELISA and TPPA were employed to detect the serum antibodies. Results The morbidity of syphilis was 2.7% in 2005,4.0% in 2006 and 8.7% in 2007.The rate of each staging is 55.9%,33.8%,1.5% and 8.8% in 2005, 73.9%,20.4%,0.7% and 5.0% in 2006 and 61.3%, 32.1%,0.6% mad 6.2% in 2007. The sensitivity and specificity were 77%and 82%for TRUST, 87% and 95%for ELISA and 68% and 100% for TPPA. The feature of epidemiology indicate that there was a significant difference in male female ratio, civilization, age distribution, occupation and marriage. Conclusion There were significant higher sensitivity for ELISA and higher specificity for TPPA among three.