Fundamental Role of microRNAs in Androgen‐Dependent Male Reproductive Biology and Prostate Cancerogenesis |
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| Authors: | Krassimira Todorova Milcho Mincheff Soren Hayrabedyan Jana Mincheva Diana Zasheva Aleksandar Kuzmanov Nelson Fernández |
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| Affiliation: | 1. Institute of Biology and Immunology of Reproduction, BAS, , Sofia, Bulgaria;2. National Specialized Hospital for Active Treatment of Haematological Diseases, , Sofia, Bulgaria;3. University of Basel, , Basel, Switzerland;4. School of Biological Sciences, University of Essex, , Colchester, UK |
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| Abstract: | Male reproductive failure has been linked to successive development of various urologic diseases including prostate cancer. There is strong epidemiologic data in support of this association, it is important therefore to identify the fundamental grounds that lay beneath such a connection. Male reproductive biology, as sex determined, is significantly dependent upon the hormonal regulation of androgens. With the advancement of knowledge on androgen receptivity and epigenetic regulation, the role of new regulatory factors such as microRNAs becomes essential. This review focuses on unraveling the role of microRNA tight incorporation in androgen‐dependent male reproductive biology in the context of recent prostate cancer data. |
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| Keywords: | Androgen receptor microRNA prostate cancer |
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