944例高血压患者中医证素与体质的相关性研究

目的:探讨高血压患者中医证素与体质的相关性。方法:对纳入的944例高血压患者进行调查,收集四诊资料,进行证素判断与中医体质判定,采用Logistic回归分析方法研究体质与证素的相关性。结果:病性证素分布依次为:阳虚(28.4%)、内火(20.8%)、阴虚(17.9%)、阳亢(8.3%)、气虚(7.8%)、痰浊(6.4%)、血虚(4.4%)、血瘀(3.6%)、肝风(1.5%)、气滞(1.0%),虚性证素以阳虚、内火和阴虚证素为主,实性证素以痰浊、血瘀为主;偏颇体质由高至低顺序为:痰湿质(30.6%)阴虚质(28.0%)阳虚质(18.8%)湿热质(12.3%)气虚质(4.7%)瘀血质(3.9%)气郁质(1.2%);以痰湿质、阴虚质、阳虚质、湿热质为最常见的4种偏颇体质;高血压患者中医证素与体质差异经检验有显著统计学意义(χ2=425.88,P0.01)。回归分析提示阴虚质与阳亢、阳虚质与阳虚回归系数为正,说明阴虚质患者对阳亢证素呈正相关,阳虚质患者对阳虚证素呈正相关;气虚质与内火、血瘀、阴虚、阳虚回归系数为负,表明气虚质对这些证素负相关。结论:阳虚、内火和阴虚证素为高血压患者主要证素;痰湿质、阴虚质、阳虚质、湿热质为最常见的4种偏颇体质,高血压患者证素与体质有一定相关性。

Correlation between Syndrome Elements and Constitution Types of Traditional Chinese Medicine in 944 Patients with Hypertension

Objective:To explore the correlation between syndrome elements and constitution types of traditional Chinese medicine(TCM) in patients with hypertension. Methods:There were 944 patients with hypertension included. After the data collection of four diagnosis,the syndrome elements and constitution types of the patients were determined,and the correlation between syndrome elements and constitution types were studied using Logistic regression analysis. Results:The distribution of syndrome elements was as follows:yang deficiency(28.4%),internal fire(20.8%),yin deficiency(17.9%),yang hyperactivity(8.3%),qi deficiency(7.8%),phlegm turbidity(6.4%),blood deficiency(4.4%),blood stasis(3.6%),liver wind(1.5%),and qi stagnation(1.0%). The deficient syndrome elements mainly were yang deficiency,internal fire and yin deficiency,while the excessive syndrome elements mainly were phlegm turbidity and blood stasis. The frequency of constitution types from high to low was:phlegm dampness(30.6%),yin deficiency(28.0%),yang deficiency(18.8%),damp heat(12.3%),qi deficiency(4.7%),blood stasis(3.9%) and qi stagnation(1.2%). The most common TCM constitution types include phlegm dampness,yin deficiency,yang deficiency,and damp heat. There were significant differences between syndrome elements and constitution types in patients with hypertension(χ2=425.88,P<0.01). According to Logistic regression analysis,the regression coefficient was positive for the correlation between yin deficiency constitution type and yang hyperactivity syndrome element,and for the correlation between yang deficiency constitution type and yang deficiency syndrome element,indicating that yin deficiency constitution type was positively correlated with yang hyperactivity syndrome element,and yang deficiency constitution type was positively correlated with yang deficiency syndrome elements. The regression coefficient was negative for the correlation between qi deficiency constitution type and syndrome elements like internal fire,blood stasis,yin deficiency and yang deficiency,indicating that qi deficiency constitution type was negatively correlated with these syndrome elements. Conclusions:The major syndrome elements in patients with hypertension are yang deficiency,internal fire and yin deficiency and the most common TCM constitution types includes phlegm dampness,yin deficiency,yang deficiency and damp heat. There is correlation between TCM syndrome elements and constitution types in patients with hypertension to a certain degree.