The combined effects of developmental lead and ethanol exposure on hippocampus dependent spatial learning and memory in rats: Role of oxidative stress |
| |
| Affiliation: | 1. Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran;2. Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Department of Physiology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;4. Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran;5. Neurophysiology Research Center, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;1. Department of Obstetrics and Gynecology and Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine and Infertility, Weill Cornell Medicine, New York, NY, USA;2. Department of Health Sciences, University of Florence, AOUCareggi, Florence, Italy;1. Department of Molecular Medicine, University “La Sapienza” Rome, Italy;2. Institute of Human Physiology, Catholic University, Rome, Italy;3. Institute of Obstetrics and Gynaecology, Catholic University, Rome, Italy;1. Department of Psychology, University of Maine, Orono, ME 04469, USA;2. School of Biology and Ecology, University of Maine, Orono, ME 04469, USA;3. Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME 04469, USA;1. National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100021, China;2. Key Laboratory of Food Safety Risk Assessment of Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China;1. Department of Histology and Embryology, Chongqing Medical University, Chongqing 400016, People’s Republic of China;2. Laboratory of Stem Cells and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University, Chongqing 400016, People’s Republic of China;3. Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine (Ministry of Education), Chongqing Medical University, Chongqing 400016, People’s Republic of China;4. Department of Geriatrics, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, People’s Republic of China;5. Department of Physiology, Chongqing Medical University, Chongqing 400016, People’s Republic of China |
| |
| Abstract: | Either developmental lead or ethanol exposure can impair learning and memory via induction of oxidative stress, which results in neuronal damage. we examined the effect of combined exposure with lead and ethanol on spatial learning and memory in offspring and oxidative stress in hippocampus. Rats were exposed to lead (0.2% in drinking water) or ethanol (4 g/kg) either individually or in combination in 5th day gestation through weaning. On postnatal days (PD) 30, rats were trained with six trials per day for 6 consecutive days in the water maze. On day 37, a probe test was done. Also, oxidative stress markers in the hippocampus were also evaluated. Results demonstrated that lead + ethanol co-exposed rats exhibited higher escape latency during training trials and reduced time spent in target quadrant, higher escape location latency and average proximity in probe trial test. There was significant decrease in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities and increase of malondialdehyde (MDA) levels in hippocampus of animals co-exposed to lead and ethanol compared with their individual exposures. We suggest that maternal consumption of ethanol during lead exposure has pronounced detrimental effects on memory, which may be mediated by oxidative stress. |
| |
| Keywords: | Lead Ethanol Spatial memory Oxidative stress Rat |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
