| 川芎嗪对脑缺血——再灌注大鼠神经功能及神经电生理的影响 |
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| 引用本文： | 方征宇,熊亮,黄杰,杨唐柱,马玉娟,尤春景.川芎嗪对脑缺血——再灌注大鼠神经功能及神经电生理的影响[J].山东医药,2010,50(2):19-20. |
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| 作者姓名： | 方征宇 熊亮 黄杰 杨唐柱 马玉娟 尤春景 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院,武汉,430030 |
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| 摘 要： | 目的观察腹腔注射川芎嗪对脑缺血—再灌注大鼠神经功能及神经电生理的影响。方法将20只大鼠随机分为A、B组，制作大鼠大脑中动脉栓塞模型后，分别腹腔注射生理盐水及川芎嗪80mg／kg，2次／d，连用7d。采用双盲法行大鼠神经功能评分，采用TTC染色法测量大鼠脑梗死灶体积，并行运动诱发电位检测。结果A组神经功能评分为（3．31±0．23）分，脑梗死灶体积为（45．63±12．75）mm^3，运动阈值为52．67％±8．75％，B组分别为（2．30±0．15）分、（26．59±7．64）mm^3、34．29％±5．18％，P均〈0．05。损伤后的运动阈值与脑梗死灶体积呈正相关（r=0．68，P〈0．05）。结论川芎嗪可减小缺血—再灌注损伤脑组织梗死灶体积，提高皮质兴奋性。
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| 关 键 词： | 川芎嗪 脑缺血 再灌注损伤 大鼠 诱发电位 运动阅值 |
Neuroelectrophysiologic effect of ligustrazine in cerebral ischemia-reperfusion injury rats |
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| FANG Zheng-yu,XIONG Liang,HUANG Jie,YANG Tang-zhu,MA Yu-juan,YOU Chun-jing.Neuroelectrophysiologic effect of ligustrazine in cerebral ischemia-reperfusion injury rats[J].Shandong Medical Journal,2010,50(2):19-20. |
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| Authors: | FANG Zheng-yu XIONG Liang HUANG Jie YANG Tang-zhu MA Yu-juan YOU Chun-jing |
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| Institution: | FANG Zheng-yu,XIONG Liang,HUANG Jie,YANG Tang-zhu,MA Yu-juan,YOU Chun-jing(Tongji Hospital,Tongji Medical College,Huazhong University of Science , Technology,Wuhan 430030,P.R.China) |
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| Abstract: | Objective To observe the effects of ligustrazine on neurvous function and cortical excitability of rats with cerebral ischemia-reperfusion injury.Methods 50 Healthy male SD rats were randomly divided into 5 groups: sham operation group,model group,low-dose ligustrazine group(20 mg/kg),middle-dose ligustrazine group(40 mg/kg),high-dose ligustrazine group(80 mg/kg).All medications were given intraperitoneally twice a day for 7 days.Motor threshold(MT),motor evoked potential(MEP) and the scores of neurological... |
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| Keywords: | ligustrazine brain ischemia reperfusion injury evoked potentials motor threshold |
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