依沙丫啶用于瘢痕子宫中期引产的安全性研究

目的:探讨终止瘢痕子宫中期妊娠安全有效的方法。方法:采用回顾性对照分析,对85例瘢痕子宫中期妊娠和260例非瘢痕子宫中期妊娠要求终止妊娠者应用依沙丫啶经腹羊膜腔内注射的引产方法进行对比分析,比较两组患者用药到宫缩发动时间、分娩时间、出血量、清宫情况、疼痛分级、软产道损伤、引产并发症发生率及住院天数的差异。结果:瘢痕子宫组与非瘢痕子宫组的宫缩时间、排胎时间、住院天数差异无统计学意义(P>0.05);疼痛分级、出血量两组差异有统计学意义(P<0.05);并发症包括产道裂伤、胎盘粘连、中期引产出血、引产感染、流产不全、羊水栓塞等瘢痕组发生率17.64%,非瘢痕组发生率8.84%,两组比较差异有统计学意义(P<0.05)。结论:依沙丫啶经腹羊膜腔内注射用于瘢痕子宫中期妊娠引产是一种安全有效的方法;相对于非瘢痕子宫,瘢痕子宫的引产并发症发生率更严重。

Research on safety of ethacridine in induced abortion at second trimester in cases with scar uterus

Objective:To explore a safe and effective method for induced abortion at second trimester in cases with scar uterus.Methods:A retrospective comparative analysis was used in the study; the methods for induced abortion at second trimester of 85 cases with scar uterus and 260 cases without scar uterus were compared and analyzed, induced abortion was carried out by transabdominal amniotic cavity injection of ethacridine; the activation time of uterine contraction, delivery time, blood loss, status of uterine curettage, grades of pain, the incidences of soft birth canal injury and complications during induced abortion, hospitalization time in the two groups were compared.Results:There was no significant difference in activation time of uterine contraction, delivery time and hospitalization time between the two groups (P>0.05); there was significant difference in grades of pain and blood loss between the two groups (P<0.05); the complications included birth canal injury, adherent placenta, bleeding during induced abortion, infection, incomplete abortion and amniotic fluid embolism, the incidences of complications in scar uterus group and non-scar uterus group were 17.64% and 8.84%, respectively, there was significant difference between the two groups (P<0.05) .Conclusion:Transabdominal amniotic cavity injection of ethacridine is a safe and effective method for induced abortion at second trimester in cases with scar uterus, the complications of induced abortion in cases with scar uterus are more severe than those in cases without scar uterus.