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| 高效液相色谱法测定眩痛定胶囊中延胡索乙素含量 | |
| 引用本文： | 曹健,王芳,陈琳,张恩娟. 高效液相色谱法测定眩痛定胶囊中延胡索乙素含量[J]. 中国药业, 2010, 19(3): 26-27 |
| 作者姓名： | 曹健 王芳 陈琳 张恩娟 |
| 作者单位： | 第三军医大学新桥医院药学部,重庆,400037 |
| 摘 要： | 目的建立测定眩痛定胶囊中延胡索乙素含量的高效液相色谱法。方法采用反相高效液相色谱法，色谱柱为Hypersil ODS柱（150mm×4.6mm，5μm），流动相为含0．2％三乙胺的水一甲醇（52：48），检测波长283nm，流速1．2mL／min。结果延胡索乙素质量浓度在8．0～40．0μg／mL范围内与峰面积呈良好的线性关系，回归方程为A=16576．5C-16466．5（r=0．9999），平均回收率为99．72％。RSD为2．88％。结论该法适用于眩痛定胶囊中延胡索乙素的含量测定。 |
| 关 键 词： | 高效液相色谱法 眩痛定胶囊 延胡索乙素 |
Determination of Tetrahydropalmatine in Xuantongding Capsule by HPLC |
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| Cao Jian,Wang Fang,Chen Lin,Zhang Enjuan. Determination of Tetrahydropalmatine in Xuantongding Capsule by HPLC[J]. China Pharmaceuticals, 2010, 19(3): 26-27 | |
| Authors: | Cao Jian Wang Fang Chen Lin Zhang Enjuan |
| Affiliation: | (Department of Pharmacy, Xinqiao Hospital, Third Military Medical University, Chongqing, China 400037) |
| Abstract: | Objective To establish a HPLC method for the determination of tetrahydropalmatine in Xuantongding Capsule. Methods The determination was performed on Hypersil ODS column （150mm×4.6mm,5μm）.The mobile phase consisted of water（containing 0. 2% triethylamine）-methanol（52：48） with the flow rate of 1.2 mL/min and the detective wavelength of 283 nm. Results The linear sample size range for tetrabydropalmatine was 8.0-40. 0 μg/mL, the equation was A = 16 576. 5 C-16466.5（ r=0. 999 9）. The average recovery rate was 99.72%, RSD = 2. 88%. Conclusion The method is suitable for the quality control of tetrahydropalmatine in Xuantongding Capsule. |
| Keywords: | HPLC Xuantongding Capsule tetrahydropalmatine |
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