心脉隆注射液对急性心肌梗死患者脑钠肽的影响及其临床意义

目的探讨心脉隆注射液对急性心肌梗死患者脑钠肽(BNP)的影响及其临床意义。方法 112例患者随机分为2组,试验组59例,对照组53例。两组均按急性心肌梗死治疗指南进行处置,对照组患者接受抗血小板、抗凝、降脂、降压、扩张冠状动脉等方面治疗,试验组在此基础上加用心脉隆静脉滴注,每天2次,连续使用5d。将两组患者的血BNP浓度及预后进行比较。结果两组患者入院即刻血BNP浓度差异无统计学意义,第5天试验组血BNP浓度明显低于对照组(P<0.01);试验组并发症总发生率(12%)明显低于对照组(28%)(P<0.05),试验组心力衰竭4例(7%)、梗死后心绞痛2例(3%),与对照组分项比较差异显著。结论心脉隆注射液能有效降低急性心肌梗死患者脑钠肽的浓度,有效减少住院期间心脏事件的发生。

The Effect and Clinical Siginificance of Xinmailong Injection on Plasma Brain Natriuretic Peptide in Acute Myocardial Infarction

Objective To explore the effect and clinical siginificance of Xinmailong injection on plasma brain natriuretic peptide(BNP)in acute myocardial infarction(AMI).Methods 112 cases with AMI were randomly divided into treatment group(group A,n=59)and control group(group B,n=53).All patients who treated with anti-platelet,anticoagulation,therapies for lowering blood-lipids and blood pressure and dilatation of coronary artery underwent medicine therapy on AMI guideline,and the patients in group A were added Xinmailong injection which be used twice a day for five days,while the patients in group B without.The data of both groups were compared with BNP concentrations and prognosis.Results There was no significant difference(P>0.05)in group A and B of BNP concentrations at admission,but was significant difference 5 days after hospitalization.The complication rate in group A(12%)was significantly lower than that in group B(28%).In group A,there were 4 cases of heart failure(7%)and 2 cases of post-infarction angina pectoris(3%).The above indexes were significantly different between A and B group.Conclusion It demonstrated that Xinmailong injection could decrease the level of BNP in AMI patients,as well as reduce cardiac events in hospital.