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副蛋白血症性神经病
引用本文:周小平,栾丽芹,蒋雨平. 副蛋白血症性神经病[J]. 中国临床神经科学, 2008, 16(5): 520-525
作者姓名:周小平  栾丽芹  蒋雨平
作者单位:1. 江苏省镇江市第一人民医院神经内科,212100
2. 复旦大学附属华山医院神经内科,200040
摘    要:
副蛋白血症与数种周围神经病(PN)有关,在PN患者中识别单克隆球蛋白(M蛋白)的存在很重要,M蛋白持续增高可能与未定性的单克隆球蛋白病(MGUS)和PN同时存在。因此,MGUS多发性PN被认为是M蛋白所介导的自身免疫疾病,本文就PN患者体内M蛋白的存在进行阐述,同时简要分析了其作用机制。

关 键 词:副蛋白血症  M蛋白  周围神经病  未定性的单克隆球蛋白病

Paraproteinemia Neuropathy
ZHOU Xiao-Ping,LUAN Li-Qin,JIANG Yu-Ping. Paraproteinemia Neuropathy[J]. Chinese Journal of Clinical Neurosciences, 2008, 16(5): 520-525
Authors:ZHOU Xiao-Ping  LUAN Li-Qin  JIANG Yu-Ping
Affiliation:ZHOU Xiao-Ping LUAN Li-Qin~1 JIANG Yu-Ping~2 1 Department of Neurology,The First People's Hospital,Zhenjiang 212100,2 Department of Neurology,Huanshan Hospital,Fudan University,Shanghai 200040,China
Abstract:
Paraproteinemia is associated with several peripheral neuropathies.It is important to identify the presence of the M protein in patients who have peripheral neuropathy.There exists consistent overrepresentation of M protein in patients who have monoclonal gammopathy of undetermined significance(MGUS)and peripheral neuropathies.Polyneuropathy associated with MGUS is believed an autoimmune disorder mediated by pathologenic activity of the M protein.The main content of this article is the review of monoclonal ...
Keywords:paraproteinemia  M-protein  peripheral neuropathy  monoclonal gammopathy of undetermined significance  
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