浅谈中西医结合系统防治急性移植物抗宿主病

急性移植物抗宿主病(aGvHD)是异基因造血干细胞移植受者一个重要的致死因素,防治aGvHD的关键在于阻止大量细胞因子引发对受者的剧烈免疫反应和组织器官损伤。文章分别归纳了当前中医与西医对aGvHD的理论研究,并进一步探讨了天然免疫抑制剂雷公藤内酯、苦参碱等与经典西药免疫抑制剂环孢素A联用防治a GvHD的研究,最后发现将经典的免疫抑制疗法结合中医药理论以扶正固本兼攻毒袪邪之药方配合移植患者治疗,可能有助于控制a GvHD的发生和发展。因此,提出中西医结合系统防治aGvHD的策略,希望为缓解移植并发症提供新的思路。

Systemic prevention and treatment of acute graft-versus-host disease by integrated traditional Chinese and Western medicine

Acute graft-versus-host disease (aGvHD) threats the survival of allogeneic hematopoietic stem cell transplantation recipients. It is key to prevent cytokine storm from triggering severe immune responses and tissue damage to recipients. This review summarizes the integrative interventions of aGvHD,including the effects of natural immunosuppressants (such as triptolide and matrine) combining with classic immunosuppressants cyclosporine A in the prevention and treatment of aGvHD. It is indicated that combining immunosuppressive therapies with traditional Chinese medicine may prevent the occurrence and development of aGvHD. Therefore,we advocate a strategy for the prevention and treatment of aGvHD by integrated Chinese and western medicine,and hope to provide some new ideas for alleviating transplant complications.