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Genetic polymorphisms,forensic efficiency and phylogenetic analysis of 15 autosomal STR loci in the Kazak population of Ili Kazak Autonomous Prefecture,northwestern China |
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| Authors: | Chunmei Feng Xin Wang Xiaolong Wang Hao Yu |
| Affiliation: | 1. School of Forensic Medicine, China Medical University, Shenyang, Liaoning, PR China;2. Department of Biotechnology Laboratory, Mudanjiang Medical College, Mudanjiang, Heilongjiang, PR China;3. DNA Laboratory of Criminal Police Detachment, Suzhou Public Security Bureau, Suzhou, Jiangsu, PR China |
| Abstract: | Aim: We investigated the frequencies of 15 autosomal STR loci in the Kazak population of the Ili Kazak Autonomous Prefecture with the aim of expanding the available population information in human genetic databases and for forensic DNA analysis. Subjects and methods: Genetic polymorphisms of 15 autosomal short tandem repeat (STR) loci were analysed in 456 individuals of the Kazak population from Ili Kazakh Autonomous Prefecture, northwestern China. Results: A total of 173 alleles at 15 autosomal STR loci were found; the allele frequencies ranged from 0.5022–0.0011. The combined power of discrimination and exclusion statistics for the 15 STR loci were 0.999 999 999 85 and 0.999 998 800 65, respectively. In addition, phylogenetic analysis involving the Ili Uygur population and other relevant populations was carried out. A neighbour-joining tree and multidimensional scaling plot were generated based on Nei’s standard genetic distance. Conclusions: Results of the population comparison indicated that the Ili Uygur population was most closely related genetically to the Uygur populations from other regions in China. These findings are consistent with the historical and geographic backgrounds of these populations. |
| Keywords: | Kazak population autosomal STR forensic analysis population comparison |