| 理气宽胸活血法治疗心脏X综合征的临床研究 |
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| 引用本文： | 王贤良,毛静远,王恒和,虞东玲,王强,张运,常延平,张其梅,李红,吴慧轩,葛永彬,王占武,赵志强,赵桂峰.理气宽胸活血法治疗心脏X综合征的临床研究[J].上海中医药杂志,2009,43(1):33-35. |
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| 作者姓名： | 王贤良 毛静远 王恒和 虞东玲 王强 张运 常延平 张其梅 李红 吴慧轩 葛永彬 王占武 赵志强 赵桂峰 |
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| 作者单位： | 天津中医药大学第一附属医院心内科,天津,300193
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| 基金项目： | 上海颜德馨中医药基金会资助项目，天津市科委科技攻关计划 |
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| 摘 要： | 目的观察理气宽胸活血法治疗心脏X综合征的临床疗效并探讨其作用机制。方法将55例心脏X综合征患者随机分为治疗组（28例）和对照组（27例）。对照组予常规西药治疗；治疗组在常规西药基础上加服理气宽胸活血方，疗程2周。观察患者治疗前后心绞痛症状、中医证候、心电图、平板运动试验指标及血内皮素（ET-1）、一氧化氮（NO）、高敏C反应蛋白（hs-CRP）等指标变化。结果治疗组心绞痛疗效、中医证候疗效总有效率分别为82．14％、85．71％，对照组分别为55．56％、55．56％，治疗组心绞痛疗效及中医证候疗效均优于对照组（P〈0．05）；治疗组心电图疗效总有效率为53．57％，对照组为48．15％，两组差异无统计学意义（P〉0．05）。治疗后两组患者平板运动试验最大代谢当量均较治疗前显著提高（P〈0．05），运动持续时间显著延长（P〈0．05），运动后各导联诱发的sT段下移之和显著减小（P〈0．05），治疗组均优于对照组（P〈0．05）；两组血ET-1、hs-CRP浓度均显著降低（P〈0．05），NO浓度显著升高（P〈0．05），治疗组均优于对照组（p〈0．05）。结论理气宽胸活血法能显著改善心脏X综合征患者心绞痛症状、中医证候，改善患者运动耐量；其治疗心脏X综合征的机制，可能与其抑制血管壁的炎性反应、保护血管内皮功能有关。
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| 关 键 词： | 心脏X综合征 理气宽胸活血 心绞痛 中医证候 平板运动试验 血管内皮功能 |
Clinical Study on Qi-Regulating,Chest-Relaxing and Blood-Activating Therapy for Cardiac Syndrome X |
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| WANG Xian-liang MAO Jing-yuan WANG Heng-he YU Dong-ling WANG Qiang ZHANG Yun CHANG Yan-ping ZHANG Qi-mei LI Hong WU Hui-xuan GE Yong-bin WANG Zhan-wu ZHAO Zhi-qiang ZHAO Gui-feng First Hospital Affiliated to Tianjin University of Traditional Chinese Medicine.Clinical Study on Qi-Regulating,Chest-Relaxing and Blood-Activating Therapy for Cardiac Syndrome X[J].Shanghai Journal of Traditional Chinese Medicine,2009,43(1):33-35. |
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| Authors: | WANG Xian-liang MAO Jing-yuan WANG Heng-he YU Dong-ling WANG Qiang ZHANG Yun CHANG Yan-ping ZHANG Qi-mei LI Hong WU Hui-xuan GE Yong-bin WANG Zhan-wu ZHAO Zhi-qiang ZHAO Gui-feng First Hospital Affiliated to Tianjin University of Traditional Chinese Medicine |
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| Institution: | (First Hospital Affiliated to Tianjin University of Traditional Chinese Medicine) |
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| Abstract: | Objective To observe the clinical efficacy of qi-regulating,chest-relaxing and blood-activating therapy for cardiac syndrome X and its mechanisms.Methods Fifty -five subjects were randomized into two groups:control group in which 27 cases were treated with routine drugs and treatment group in which 28 cases were treated with the therapy above besides routine drugs,with a course of 2 weeks.The angina pectoris,Chinese medical syndrome,electrocardiogram,treadmill exercise test,and the levels of ET-1,NO and hs-... |
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| Keywords: | Cardiac syndrome X qi-regulating chest-relaxing and blood-activating therapy angina pectoris Chinese medical syndrome treadmill exercise test vascular endothelium |
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