血脂水平与卵巢上皮性肿瘤发生发展的相关性分析

目的:比较卵巢良性上皮肿瘤?早期及晚期恶性上皮肿瘤的血脂水平,探讨血脂变化在卵巢上皮肿瘤发生发展过程中可能的作用?方法:采用病例-对照研究,共纳入200例研究对象,按手术后病理结果分为良性组100例?早期恶性组和晚期恶性组各50例,收集各组血脂,主要观察总胆固醇(total cholesterol,TC)?甘油三酯(triglycerides,TG)?高密度脂蛋白胆固醇(highdensity lipoprotein cholesterol,HDL-c)?低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-c)?脂蛋白a[lipoprotein (a)]等血脂指标与卵巢上皮性肿瘤的相关关系?结果:恶性组TC及HDL-c水平明显低于良性组,差异具有统计学意义(P < 0.05),恶性组LP(a)水平也较良性组有升高的趋势(P=0.061)而LDL-c较良性组有降低趋势(P=0.061)?良性组?早期组及晚期组间TC?HDL-c?LDL-c及LP(a)水平方差分析结果均显示差异具有统计学意义(P值均 < 0.05)?其中良性组较早期组的HDL-c水平明显降低(P < 0.001);晚期组较良性组TC?HDL-c?LDL-c明显下降(P值均<0.05),而晚期组LP(a)水平较良性组明显升高(P=0.013);晚期组与早期组相比,两组之间各项指标均无明显差异,而只有LP(a)呈升高趋势(P=0.052)?将TC?TG?HDL-c,LDL-c及LP(a)作为自变量,卵巢肿瘤的病变程度作为因变量,进行Logistic分析:HDL-c(P < 0.01)及LP(a)(P = 0.02)与卵巢肿瘤的发展程度有关,差异性具有统计学意义;根据指南标准分别对其进行赋值后,再次进行Logistic回归分析:HDL-c(P < 0.01)及LDL-c(P = 0.01)与肿瘤的病变程度有关,差异性具有统计学意义?结论:HDL-c?LDL-c及LP(a)与卵巢肿瘤的发展程度有关,卵巢恶性肿瘤的期别越晚,HDL-c及LDL-c的值越低,而LP(a)值越高?

The predictive role of serum lipid profile in ovarian epithelial tumor

Objective:To compare the expression of serum lipid among ovarian benign epithelial tumor,early and late malignant epithelial tumor,and explore the possible role of blood lipids changes in the occurrence and development of epithelial ovarian tumor. Methods:Total of 200 patients with ovarian epithelial tumor was randomly collected. According to the pathological results after operation,these patients were divided into the benign group with 100 cases,early malignant group and advanced malignant group with 50 cases in each group. Serum lipids were collected,and total cholesterol (TC),triglyceride (TG),high density lipoprotein cholesterol (HDL-c),low density lipoprotein cholesterol (LDL-c),lipoprotein (a) were detected. Results:TC and HDL-c levels of malignant group were significantly lower than those in benign group(both P < 0.05). The LP (a) levels of malignant group preferred to be lower than the benign group increased (P=0.061) while the LDL-c showed a decreasing trend than those of the benign group (P=0.061). One-Way ANOVA analysis showed that LP,TC,HDL-c,and LDL-c among the three groups had significant difference(P < 0.05). Furthermore,HDL-c level of benign group was lower than that of the early group significantly (P < 0.001). TC,HDL-c,LDL-c in advanced group decreased significantly than thoses in benign group (P < 0.05),while the LP (a) level of advanced group was higher than that of the benign group (P=0.013). The advanced group and early group had no significant difference on the indicators,and only LP (a) were increased potentially (P=0.052). Logistic regression analysis showed that the level of HDL-c,LDL-c,and LP (a) was related with the development of ovarian tumor. Conclusion:HDL-c,LDL-c,and LP (a) were associated with the degree of development of ovarian epithelial tumors,the more advanced the tumor was,the lower level of HDL-c and LDL-c while the higher level of LP (a) was.