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| 不同浓度米非司酮对体外培养子宫肌瘤细胞生长的影响 | |
| 引用本文： | 杨彦,王胜军,樊洁,陈亚梅,肖群. 不同浓度米非司酮对体外培养子宫肌瘤细胞生长的影响[J]. 江苏大学学报(医学版), 2003, 13(2): 123-125 |
| 作者姓名： | 杨彦 王胜军 樊洁 陈亚梅 肖群 |
| 作者单位： | 1. 江苏大学附属镇江市第四人民医院妇产科,江苏,镇江,212002 2. 江苏大学医学技术学院免疫学研究室,江苏,镇江,212001 |
| 基金项目： | 江苏省应用基础研究指导性计划项目 (BJ2 0 0 0 316 ) |
| 摘 要： | 目的：观察米非司酮对体外培养子宫肌瘤细胞的作用。方法：采用绘制细胞生长曲线和MTT法检测了解不同浓度米非司酮对体外培养子宫肌瘤细胞生长的影响。结果：低浓度米非司酮对子宫肌瘤细胞无抑制作用，当药物浓度达到10—6mol／L时其作用才表现出来，随着浓度的增加，其抑制作用增强。结论：米非司酮对子宫肌瘤细胞的作用具有浓度依赖关系。 |
| 关 键 词： | 米非司酮 细胞培养 子宫肌瘤 MTT法 |
| 文章编号： | 1671-7783(2003)02-0123-03 |
| 修稿时间： | 2002-12-13 |
Effect of Different Concentrations of Mifepristone on Human Uterine Leiomyoma Cells in Vitro |
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| YANG Yan ,WANG Sheng-jun ,FAN Jie ,CHEN Ya-mei ,XIAO Qun. Effect of Different Concentrations of Mifepristone on Human Uterine Leiomyoma Cells in Vitro[J]. Journal of Jiangsu University Medicine Edition, 2003, 13(2): 123-125 | |
| Authors: | YANG Yan WANG Sheng-jun FAN Jie CHEN Ya-mei XIAO Qun |
| Affiliation: | YANG Yan 1,WANG Sheng-jun 2,FAN Jie 1,CHEN Ya-mei 1,XIAO Qun 1 |
| Abstract: | Objective:To observe the effect of mifepristone on the human uterine leiomyoma cells in vitro. Methods :Human uterine leiomyoma cells were treated with mifepristone at different concentrations and the growth of the cells was analyzed by plotting cell growth curve and MTT assay.Results:Lower concentration of mifepristone had no inhibitory effect on the human uterine leiomyoma cells, The effect developed when the concentration was up to 16 -6 mol/L,and the inhibitory effect of mifepristone became more significant with the increase of the concentration.Conclusions:The effect of mifepristone on human leiomyoma cells in vitro is concentration-dependent. |
| Keywords: | Mifepristone Cell culture Human uterine leiomyoma MTT assay |
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