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Oral contraceptives and the risk of venous thromboembolism: An update : No. 252, December 2010
Authors:Robert Reid  Wendy Wolfman  Alaa Awadalla  Sheila Dunn  Violaine Marcoux  Frank Potestio  Sukhbir Singh
Affiliation:
  • a Kingston, ON
  • b North York ON
  • c Toronto ON
  • d Vancouver BC
  • e Winnipeg MB
  • f Quebec QC
  • g Ville Mont-Royal QC
  • h Ottawa ON
  • i Thunder Bay ON
  • j Halifax NS
    		•
    Abstract:

    Objective

    To provide current and emerging evidence on oral contraceptives and the risk of venous thromboembolism.

    Evidence

    Articles published in English from 2005 were retrieved through searches of PubMed and Medline, using the following terms: venous thromboembolism, VTE, contraception, oral contraceptives, hormonal contraception. Results were restricted to systematic reviews, randomized control trials/controlled clinical trials, and observational studies. Searches were updated on a regular basis and incorporated in the guideline to May 2010. Grey (unpublished) literature was identified through searching the websites of health technology assessment and health technology assessment-related agencies, clinical practice guideline collections, clinical trial registries, and national and international medical specialty societies.

    Values

    The quality of evidence was rated using the criteria described by the Canadian Task Force on Preventive Health Care (Table).
    Keywords:FDA US, Food and Drug Administration   OC, oral contraceptives   VTE, venous thromboembolism
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