| STUDIES ON THE RELATIONSHIP BETWEEN CHROMOSOME No15 AND THE BIOLOGICAL CHARACTERISTICS OF MALIGNANT TRANSFORMED SYRIAN HAMSTER FIBROBLAST CELL LINES |
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| 引用本文： | 李申德,刘炳辰,许德新. STUDIES ON THE RELATIONSHIP BETWEEN CHROMOSOME No15 AND THE BIOLOGICAL CHARACTERISTICS OF MALIGNANT TRANSFORMED SYRIAN HAMSTER FIBROBLAST CELL LINES[J]. 中国医学科学杂志(英文版), 1990, 0(1) |
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| 作者姓名： | 李申德 刘炳辰 许德新 |
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| 作者单位： | Cancer Institute CAMS，Beijing，Institute of Radiation Medicine，CAMS，Tianjin.，Cancer Institute，CAMS，Beijing |
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| 摘 要： | During the course of malignant transformation of mammalian cells in vitro,a regular varia-tion in chromosome number and structure is usually found.In order to elucidate the rela-tionship between chromosomal changes and maligannt expression,we isolated fire clonesfrom a malignant transformed Syrian hamster fibroblast cell line and analyzed their biologicalcharacteristics,as well as chromosomal changes.A positive correlation betweetn chromosomeNo 15 monosomy and the transformed and malignant phenotype was observed.We suggestthat a suppression gene may be located on chromosome No 15,and its deletion or the lossof the chromosome may result in expression of the malignant phenotype.
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STUDIES ON THE RELATIONSHIP BETWEEN CHROMOSOME No15 AND THE BIOLOGICAL CHARACTERISTICS OF MALIGNANT TRANSFORMED SYRIAN HAMSTER FIBROBLAST CELL LINES |
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| Li Shende,Liu Bingchen,Xu Dexin Cancer Institute,CAMS,Beijing Institute of Radiation Medicine,CAMS,Tianjin.. STUDIES ON THE RELATIONSHIP BETWEEN CHROMOSOME No15 AND THE BIOLOGICAL CHARACTERISTICS OF MALIGNANT TRANSFORMED SYRIAN HAMSTER FIBROBLAST CELL LINES[J]. Chinese medical sciences journal, 1990, 0(1) |
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| Authors: | Li Shende Liu Bingchen Xu Dexin Cancer Institute CAMS Beijing Institute of Radiation Medicine CAMS Tianjin. |
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| Abstract: | During the course of malignant transformation of mammalian cells in vitro,a regular varia- tion in chromosome number and structure is usually found.In order to elucidate the rela- tionship between chromosomal changes and maligannt expression,we isolated fire clones from a malignant transformed Syrian hamster fibroblast cell line and analyzed their biological characteristics,as well as chromosomal changes.A positive correlation betweetn chromosome No 15 monosomy and the transformed and malignant phenotype was observed.We suggest that a suppression gene may be located on chromosome No 15,and its deletion or the loss of the chromosome may result in expression of the malignant phenotype. |
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| Keywords: | chromosome No 15 monosomy clonal cell line transformed phenotype malignant phenotype |
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