血清幽门螺杆菌抗体检测与冠心病关系初探

观察６０例心病,４２例高血压患者和６０例正常人血清幽门螺杆菌抗体载脂蛋白Ｂ１００和脂刷 白（ａ）「Ｌｐ（ａ）」旨在探讨幽门螺杆菌感染在冠心病患者的感染情况以及同血脂代谢之间的关系。结论幽门杆菌菌感染可能是冠心病发病的独立危险因子,其机理可能是长甚是性感染引起ＡＰＯＢ１００、Ｌｐ（ａ）浓度增加,因而促发ＣＨＤ发生。

INITIAL PROBE OF RELATION BETWEEN HELICOBACTER PYLORI INFECTION AND CORONARY HEART DISEASE

Objective: To determine whether Helicobacter pylori infection is associated with the development of coronary heart disease(CHD)and whether such infection has some relation with Lipemia. Methods: Hpylori IgG (Hp-IgG),Apolipoprotein B100 (APOB100 ), and Lipoprotein(a). [LP(a)] were determined serologically in 60 consecutive patients tvith CHD and 102 controls (42 with hypertension, 60 normal persons). Results: 33/60(55%) of the cases (CHD)were Hp-IgG positive as compared with 16/42(38%. P <0. 05) and 18/60 (31%, P < 0. 01) in the control group. The concentrations of APOB100 and Lp(a) were found much higher in CHD cases than in controls. HP-IgG seropositivity may be correlated with APOB100 and LP(a). Conclusions: H pylori infection may be independently asariated with the development of CHD. The Possible mechanism was that Chronic H pylori infection might increase concentrations of APOB100and LP(a) in a way that could increase the risk of CHD.