经阴道超声引导卵泡穿刺术治疗多囊卵巢综合征不孕症的临床研究

目的 探讨超声引导下经阴道穿刺未成熟卵泡对多囊卵巢综合征(PCOS)不孕患者卵巢基础窦卵泡计数及其内分泌功能的影响.方法 23例PCOS不孕患者在超声引导下进行未成熟卵泡穿刺,抽吸卵泡液,对比观察穿刺抽吸前后患者卵巢基础窦卵泡计数以及内分泌功能的变化,并观察卵巢有无恢复排卵及妊娠.结果 23例患者经过2～3个周期的穿刺治疗后,所有患者血睾酮水平均显著降低、黄体生成素(LH)与卵泡刺激素(FSH)比值也明显降低,与治疗前相比,差异有统计学意义.17例患者术后卵巢基础窦卵泡计数降至10个以下,完成卵泡穿刺治疗后连续观察6个月,共有10例患者妊娠.结论 超声引导下卵泡穿刺术能改善PCOS不孕患者内分泌状况,减少卵巢基础窦卵泡计数,促进卵巢排卵,为PCOS患者提供了一条简便可行的辅助生育治疗途径.

Treatment of polycystic ovary syndrome with infertility by ultrasound- guided immature follicle puncture

Objective To evaluate the efficacy of ultrasound-guided immature follicle puncture technique(IMFP) in patients with polycystic ovary syndrome(PCOS).Methods Ultrasound-guided immature follicle puncture was performed on 23 PCOS patients,the change of the basal endocrinology and the basic number of follicles were checked before and after puncture,and the pregnancy after the therapy was fellowed up.Results After 2 to 3 treatment cycles,the testosterone level and LH/FSH rate decreased in all patients,the basic follicle number decreased to less than 10 per ovary in 17 cases.Within 6 months after the treatment,10 patients became pregnant.Conclusion IMFP treatment can improve the abnormal endocrinology,decrease the basic follicle number of the ovary,and achieve pregnancy in following cycles in PCOS patients.