| 长期运动预适应模型大鼠心脏蛋白激酶C和热休克蛋白70的表达 |
| |
| 引用本文： | 孙晓娟,侯娜. 长期运动预适应模型大鼠心脏蛋白激酶C和热休克蛋白70的表达[J]. 中国组织工程研究与临床康复, 2011, 15(28): 5185-5188. DOI: 10.3969/j.issn.1673-8225.2011.28.014 |
| |
| 作者姓名： | 孙晓娟 侯娜 |
| |
| 作者单位： | 咸阳师范学院体育系,陕西省咸阳市,712000 |
| |
| 基金项目： | 陕西省教育厅科学研究计划项目,2010年陕西省体育局体育科研课题,咸阳师范学院专项科研基金资助重点项目 |
| |
| 摘 要： | 背景:研究表明蛋白激酶C和热休克蛋白70可能参与运动预适应的心脏保护作用。目的:观察长期运动预适应对大鼠心脏蛋白激酶C和热休克蛋白70的影响及其对心脏保护的作用机制。方法:将SD大鼠随机分为对照组,力竭运动组和运动预适应组。对照组和力竭运动组大鼠常规饲养3周,运动预适应组大鼠进行3周的间歇性游泳运动建立长期运动预适应动物模型。3周后,力竭运动组和运动预适应组大鼠进行一次性力竭游泳运动。结果与结论:大鼠力竭运动后,力竭运动组心脏热休克蛋白70表达高于对照组(P<0.05);先经3周运动预适应再进行力竭运动后,运动预适应组心脏蛋白激酶C和热休克蛋白70的表达高于力竭运动组(P<0.05)。结果证实,长期运动预适应能激活心脏蛋白激酶C,诱导热休克蛋白70的合成增多,从而发挥其心脏保护作用。
|
| 关 键 词： | 运动预适应 蛋白激酶C 热休克蛋白70 心脏 大鼠 组织工程 |
Expression of protein kinase C and heat shock protein 70 in the heart of rat models of long-term exercise preconditioning |
| |
| Sun Xiao-juan,Hou Na. Expression of protein kinase C and heat shock protein 70 in the heart of rat models of long-term exercise preconditioning[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2011, 15(28): 5185-5188. DOI: 10.3969/j.issn.1673-8225.2011.28.014 |
| |
| Authors: | Sun Xiao-juan Hou Na |
| |
| Affiliation: | Sun Xiao-juan,Hou Na Department of Physical Education,Xianyang Normal University,Xianyang 712000,Shaanxi Province,China |
| |
| Abstract: | BACKGROUND:Several studies have demonstrated that protein kinase C (PKC) and heat shock protein 70 (HSP70) take part in the cardioprotection of exercise preconditioning (EP), but the relationship and the underlying mechanism remain poorly understood. OBJECTIVE:To investigate the effects of long-term EP on PKC and HSP70 expression in the rat heart and the possible mechanism of cardioprotection. METHODS:Sprague-Dawley rats were randomly divided into the control, exhausted exercise and EP groups. Rats in the c... |
| |
| Keywords: | |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
